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Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study

Abstract : Abstract Purpose The impact of a healthy diet on asthma prevention and management, particularly among elderly women, remains poorly understood. We investigated whether a healthy diet would be associated with fewer asthma symptoms, and, among women with asthma, with reduced uncontrolled asthma and metabolic-related multimorbidity. Methods We included 12,991 elderly women (mean age = 63 years) from the Asthma-E3N study, a nested case–control study within the French E3N cohort. Negative binomial regressions were used to analyse associations between a healthy diet [evaluated by the Alternate Healthy Eating Index-2010 (AHEI-2010)] and a validated asthma symptom score, and logistic regressions to analyse associations between the AHEI-2010 with the asthma control test and multimorbidity profiles previously identified by clustering methods on medications used. Results After adjustment for potential confounders, a linear inverse association was found between the AHEI-2010 score and the asthma symptom score [mean score ratio (95% CI) = 0.82 (0.75–0.90) for the highest versus lowest quintile; p for trend < 0.0001]. In addition, women in the highest versus lowest AHEI-2010 tertile were at a lower risk to belong to the “Predominantly metabolic multimorbidity-related medications profile” compared to the “Few multimorbidity-related medications" profile [OR 0.80 (0.63–1.00) for tertile 3; p for trend = 0.05; n = 3474]. Conclusion Our results show that a healthy dietary intake could play an important role in the prevention and management of asthma over the life course.
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Contributor : Beatrice Faraldo Connect in order to contact the contributor
Submitted on : Wednesday, April 20, 2022 - 3:14:46 PM
Last modification on : Sunday, June 26, 2022 - 9:21:10 AM
Long-term archiving on: : Thursday, July 21, 2022 - 7:30:25 PM



Wassila Ait-Hadad, Annabelle Bédard, Sébastien Chanoine, Orianne Dumas, Nasser Laouali, et al.. Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study. European Journal of Nutrition, Springer Verlag, 2022, Online ahead of print. ⟨10.1007/s00394-022-02815-0⟩. ⟨inserm-03647418⟩



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