Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: From preclinical to clinical studies - Archive ouverte HAL Access content directly
Journal Articles Expert Opinion on Drug Delivery Year : 2022

Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: From preclinical to clinical studies

(1) , (1) , (1) , (1) , (1) , (1) , (2, 3) , (1, 3) , (2, 3) , (1)
1
2
3

Abstract

Introduction: The combination of microbubbles (MBs) and ultrasound (US) is an emerging method for the noninvasive and targeted enhancement of intratumor chemotherapeutic uptake. This method showed an increased local drug extravasation in tumor tissue while reducing the systemic adverse effects in various tumor models. Area covered: We focused on preclinical and clinical studies investigating the therapeutic efficacy and safety of this technology for the treatment of colorectal, pancreatic and liver cancers. We discussed the limitations of the current investigations and future perspectives. Expert opinion: The therapeutic efficacy and the safety of delivery of standard chemotherapy regimen using MB-assisted US have been mainly demonstrated in subcutaneous models of digestive cancers. Although some clinical trials on pancreatic ductal carcinoma and hepatic metastases from various digestive cancers have shown promising results, successful evaluation of this method in terms of US settings, chemotherapeutic schemes and MBs-related parameters will need to be addressed in more relevant preclinical models of digestive cancers, in small and large animals before fully and successfully translating this technology for clinic use. Ultimately, a clear evidence of the correlation between the enhanced intratumoral concentrations of therapeutics and the increased therapeutic response of tumors have to be provided in clinical trials.
Fichier principal
Vignette du fichier
EODD.pdf (1.02 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-03626073 , version 1 (31-03-2022)

Identifiers

Cite

Jean-Michel Escoffre, Najib Sekkat, Edward Oujagir, Sylvie Bodard, Coralie Mousset, et al.. Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: From preclinical to clinical studies. Expert Opinion on Drug Delivery, 2022, Online ahead of print. ⟨10.1080/17425247.2022.2061459⟩. ⟨inserm-03626073⟩

Collections

INSERM UNIV-TOURS
13 View
19 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More