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Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study

Abstract : Background: Compared with standard karyotype, chromosomal microarray analysis improves the detection of genetic anomalies and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of chromosomal microarray analysis in cases of isolated fetal growth restriction. Objective: This study aimed to estimate the proportion of copy number variants detected by chromosomal microarray analysis and the incremental yield of chromosomal microarray analysis compared with karyotype in the detection of genetic abnormalities in fetuses with isolated fetal growth restriction. Study design: This retrospective study included all singleton fetuses diagnosed with fetal growth restriction and no structural ultrasound anomalies and referred to 13 French fetal medicine centers over 1 year in 2016. Fetal growth restriction was defined as an estimated fetal weight of
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https://www.hal.inserm.fr/inserm-03617447
Contributor : Florent Fuchs Connect in order to contact the contributor
Submitted on : Wednesday, March 23, 2022 - 2:44:16 PM
Last modification on : Wednesday, September 28, 2022 - 6:00:56 AM

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Isabelle Monier, Aline Receveur, Véronique Houfflin-Debarge, Valérie Goua, Vanina Castaigne, et al.. Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study. American Journal of Obstetrics and Gynecology, Elsevier, 2021, 225 (6), pp.676.e1-676.e15. ⟨10.1016/j.ajog.2021.05.035⟩. ⟨inserm-03617447⟩

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