Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue American Journal of Obstetrics and Gynecology Année : 2021

Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study

Thierry Rousseau
  • Fonction : Auteur
Anne-Sylvie Valat
  • Fonction : Auteur
Florent Fuchs
Guillaume Benoist
  • Fonction : Auteur
Sophie Degre
  • Fonction : Auteur

Résumé

Background: Compared with standard karyotype, chromosomal microarray analysis improves the detection of genetic anomalies and is thus recommended in many prenatal indications. However, evidence is still lacking on the clinical utility of chromosomal microarray analysis in cases of isolated fetal growth restriction.Objective: This study aimed to estimate the proportion of copy number variants detected by chromosomal microarray analysis and the incremental yield of chromosomal microarray analysis compared with karyotype in the detection of genetic abnormalities in fetuses with isolated fetal growth restriction.Study design: This retrospective study included all singleton fetuses diagnosed with fetal growth restriction and no structural ultrasound anomalies and referred to 13 French fetal medicine centers over 1 year in 2016. Fetal growth restriction was defined as an estimated fetal weight of
Fichier principal
Vignette du fichier
S0002937821006037.pdf (284.82 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

inserm-03617447 , version 1 (05-01-2024)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Isabelle Monier, Aline Receveur, Véronique Houfflin-Debarge, Valérie Goua, Vanina Castaigne, et al.. Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? A French multicenter study. American Journal of Obstetrics and Gynecology, 2021, 225 (6), pp.676.e1-676.e15. ⟨10.1016/j.ajog.2021.05.035⟩. ⟨inserm-03617447⟩
45 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More