Antibody Responses after a Third Dose of COVID-19 Vaccine in Kidney Transplant Recipients and Patients Treated for Chronic Lymphocytic Leukemia - Archive ouverte HAL Access content directly
Journal Articles Vaccines Year : 2021

Antibody Responses after a Third Dose of COVID-19 Vaccine in Kidney Transplant Recipients and Patients Treated for Chronic Lymphocytic Leukemia

(1) , (1) , (2, 1) , (3) , (4) , (1)
1
2
3
4

Abstract

The impact of a third dose of COVID-19 vaccine on antibody responses is unclear in immunocompromised patients. The objective of this retrospective study was to characterize antibody responses induced by a third dose of mRNA COVID-19 vaccine in 160 kidney transplant recipients and 20 patients treated for chronic lymphocytic leukemia (CLL). Prevalence of anti-spike IgG ≥ 7.1 and ≥ 30 BAU/mL after the third dose were 47% (75/160) and 39% (63/160) in kidney transplant recipients, and 57% (29/51) and 50% (10/20) in patients treated for CLL. Longitudinal follow-up identified a moderate increase in SARS-CoV-2 anti-spike IgG levels after a third dose of vaccine in kidney transplant recipients (0.19 vs. 5.28 BAU/mL, p = 0.03) and in patients treated for CLL (0.63 vs. 10.7 BAU/mL, p = 0.0002). This increase in IgG levels had a limited impact on prevalence of anti-spike IgG ≥ 30 BAU/mL in kidney transplant recipients (17%, 2/12 vs. 33%, 4/12, p = 0.64) and in patients treated for CLL (5%, 1/20 vs. 45%, 9/20, p = 0.008). These results highlight the need for vaccination of the general population and the importance of non-medical preventive measures to protect immunocompromised patients.
Fichier principal
Vignette du fichier
Marlet et al. - 2021 - Antibody Responses after a Third Dose of COVID-19 .pdf (578.48 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-03615683 , version 1 (21-03-2022)

Identifiers

Cite

Lynda Handala, Sébastien Eymieux, Julien Marlet, Emmanuel Gyan, Caroline Dartigeas, et al.. Antibody Responses after a Third Dose of COVID-19 Vaccine in Kidney Transplant Recipients and Patients Treated for Chronic Lymphocytic Leukemia. Vaccines, 2021, 9 (10), pp.1055. ⟨10.3390/vaccines9101055⟩. ⟨inserm-03615683⟩

Collections

INSERM UNIV-TOURS
14 View
17 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More