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Journal Articles NPJ Regenerative medicine Year : 2021

Pain sensing neurons promote tissue regeneration in adult mice

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Gilles Mithieux

Abstract

Abstract Tissue repair after injury in adult mammals, usually results in scarring and loss of function in contrast to lower vertebrates such as the newt and zebrafish that regenerate. Understanding the regulatory processes that guide the outcome of tissue repair is therefore a concerning challenge for regenerative medicine. In multiple regenerative animal species, the nerve dependence of regeneration is well established, but the nature of the innervation required for tissue regeneration remains largely undefined. Using our model of induced adipose tissue regeneration in adult mice, we demonstrate here that nociceptive nerves promote regeneration and their removal impairs tissue regeneration. We also show that blocking the receptor for the nociceptive neuropeptide calcitonin gene-related peptide (CGRP) inhibits regeneration, whereas CGRP administration induces regeneration. These findings reveal that peptidergic nociceptive neurons are required for adult mice tissue regeneration.
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Origin : Publication funded by an institution

Dates and versions

inserm-03582911 , version 1 (21-02-2022)

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Lise Rabiller, Elodie Labit, Christophe Guissard, Silveric Gilardi, Bruno Guiard, et al.. Pain sensing neurons promote tissue regeneration in adult mice. NPJ Regenerative medicine, 2021, 6 (1), pp.63. ⟨10.1038/s41536-021-00175-7⟩. ⟨inserm-03582911⟩
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