Role of mitochondria-associated endoplasmic reticulum membrane (MAMs) interactions and calcium exchange in the development of type 2 diabetes - Archive ouverte HAL Access content directly
Book Sections International review of cell and molecular biology / Int Rev Cell Mol Biol Year : 2021

Role of mitochondria-associated endoplasmic reticulum membrane (MAMs) interactions and calcium exchange in the development of type 2 diabetes

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Abstract

Glucotoxicity-induced β-cell dysfunction in type 2 diabetes is associated with alterations of mitochondria and the endoplasmic reticulum (ER). Mitochondria and ER form a network in cells that controls cell function and fate. Mitochondria of the pancreatic β cell play a central role in the secretion of insulin in response to glucose through their ability to produce ATP. Both organelles interact at contact sites, defined as mitochondria-associated membranes (MAMs), which were recently implicated in the regulation of glucose homeostasis. Here, we review MAM functions in the cell and we focus on the crosstalk between the ER and Mitochondria in the context of T2D, highlighting the pivotal role played by MAMs especially in β cells through inter-organelle calcium exchange and glucotoxicity-associated β cell dysfunction.
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Dates and versions

inserm-03582082 , version 1 (21-02-2022)

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A. M. Madec, J. Perrier, Baptiste Panthu, F. Dingreville. Role of mitochondria-associated endoplasmic reticulum membrane (MAMs) interactions and calcium exchange in the development of type 2 diabetes. International Review of Cell and Molecular Biology, 363, pp.169-202, 2021, ⟨10.1016/bs.ircmb.2021.06.001⟩. ⟨inserm-03582082⟩
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