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Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry

M. Sokolski 1, 2 S. Trenson 2, 3 J. M. Sokolska 1, 2 D. d'Amario 4, 5 P. Meyer 6 N. K. Poku 6 T. Biering-Sørensen 7, 8 M. C. Højbjerg Lassen 7, 8 K. G. Skaarup 7, 8 E. Barge-Caballero 9, 10, 11 A. C. Pouleur 12, 13 D. Stolfo 14 G. Sinagra 14 K. Ablasser 15 V. Muster 15 P. P. Rainer 15 M. Wallner 15, 16, 17 A. Chiodini 2 P. S. Heiniger 2 F. Mikulicic 2 J. Schwaiger 2 S. Winnik 2 H. A. Cakmak 18 M. Gaudenzi 19, 20 M. Mapelli 19, 20 I. Mattavelli 19 M. Paul 21, 22 I. Cabac-Pogorevici 23 C. Bouleti 24 M. Lilliu 25 C. Minoia 26 J. Dauw 27, 28 J. Costa 29 A. Celik 30 N. Mewton 31, 32, 33 C. E. L. Montenegro 34 Y. Matsue 35 G. Loncar 36, 37 M. Marchel 38 A. Bechlioulis 39 L. Michalis 39 M. Dörr 40, 41 E. Prihadi 42 F. Schoenrath 43, 41 D. R. Messroghli 41, 44, 45 W. Mullens 27 L. H. Lund 46, 47 G. M. C. Rosano 48 P. Ponikowski 49 F. Ruschitzka 2 A. J. Flammer 2 
19 Centro Cardiologico Monzino [Milano]
DISCCO - Dpt di Scienze Cliniche e di Comunità [Milano], IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
Abstract : AIMS: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. METHODS AND RESULTS: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P \textless 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P \textless 0.001). CONCLUSIONS: Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.
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Submitted on : Monday, February 21, 2022 - 8:00:28 AM
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M. Sokolski, S. Trenson, J. M. Sokolska, D. d'Amario, P. Meyer, et al.. Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry. ESC Heart Failure, Wiley, 2021, 8 (6), pp.4955-4967. ⟨10.1002/ehf2.13549⟩. ⟨inserm-03582037⟩

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