Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue BMC Neurology Année : 2021

Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage

Résumé

Background: Cognitive impairment and depressive symptoms are highly prevalent after Intracerebral Hemorrhage (ICH). We leveraged Latent Profile Analysis (LPA) to identify profiles for cognitive decline and depression onset after ICH. We also investigated differences in clinical, genetic and neuroimaging characteristics across patients' profiles. Methods: We analyzed data from the ICH study conducted at Massachusetts General Hospital between January 1998 and December 2019. We collected information from electronical health records, follow-up interviews, CT and MRI imaging, and APOE genotype. We conducted LPA and multinomial logistic regression analyses to: 1) identify distinct profiles for cognitive decline and depression onset after ICH; 2) identify clinical, neuroimaging and genetic factors predicting individuals' likelihood to express a specific profile. Results: We followed 784 ICH survivors for a median of 45.8 months. We identified four distinct profiles in cognitive and depressive symptoms after ICH: low depression and dementia risk, early-onset depression and dementia, lateonset depression and dementia, high depression with low dementia risk. Cerebral small vessel disease severity and APOE genotype were specifically associated with the late-onset profile (both p < 0.05). Acute hematoma characteristics (size, intraventricular extension) and functional disability were specifically associated with the early-onset profile (all p < 0.05). Conclusion: We identified four distinct profiles for cognitive and depressive symptoms after ICH, each displaying specific associations with individual patients' clinical, genetic and neuroimaging data. These associations reflect separate biological mechanisms influencing dementia and depression risk after ICH. Our findings support employing LPA in future ICH studies, and is likely applicable to stroke survivors at large.
Fichier principal
Vignette du fichier
s12883-021-02508-x.pdf (1.88 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

inserm-03553073 , version 1 (02-02-2022)

Identifiants

Citer

Sophia Keins, Jessica R Abramson, Juan Pablo Castello, Marco Pasi, Andreas Charidimou, et al.. Latent profile analysis of cognitive decline and depressive symptoms after intracerebral hemorrhage. BMC Neurology, 2021, 21 (1), pp.481. ⟨10.1186/s12883-021-02508-x⟩. ⟨inserm-03553073⟩

Collections

INSERM UNIV-LILLE
21 Consultations
22 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More