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Serum soluble CD23 levels in giant cell arteritis'

Abstract : Lymphocytes and monocytes express various levels of membrane-bound CD23, the low affinity receptor for IgE (FceRII), and in some cases release it as a soluble form. Soluble CD23 (sCD23) has been implicated in the regulation of many immunological functions of T and B lymphocytes, macrophages and myeloid cells in humans. To study serum sCD23 levels in inflammatory conditions, we selected a systemic disease sensitive to corticotherapy, the giant cell arteritis, which is characterized by an inflammation of the temporal artery. Serum sCD23 levels, as measured by a radioimmunoassay, were increased in these patients, and returned to normal values within the 24 h following initiation of corticotherapy. The data suggest that the increase in sCD23 levels in giant cell arteritis results from an overproduction.
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Contributor : Eric Lelievre Connect in order to contact the contributor
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Pascal Roblot, Franck Morel, Eric Lelièvre, Marie-Hélène Biais-Sauvètre, Donat de Groote, et al.. Serum soluble CD23 levels in giant cell arteritis'. Immunology Letters, Elsevier, 1996, 53 (1), pp.41. ⟨10.1016/0165-2478(96)02612-0⟩. ⟨inserm-03549093⟩



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