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Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators.

Abstract : Since the 80s, intrigued by presence of morphine precursors in some mammalian cells, different laboratories were able to characterize morphine and morphine precursors in animal tissues. Endogenous morphine studies continued during 90s and this alkaloid was successfully characterized from more organs and fluids of vertebrates, including brain, adrenal gland, heart, cerebrospinal fluid and urine. Then, in the last three years a high rate of publications dealing with this topic emerged, leading to a better understanding of the endogenous morphine system. In this regard, this article comment all the new data recently collected on this rising subject and replace the morphine and its derivative, morphine-6-glucuronide, in the mammalian physiology.
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https://www.hal.inserm.fr/inserm-03543894
Contributor : Yannick Goumon Connect in order to contact the contributor
Submitted on : Wednesday, January 26, 2022 - 12:07:30 PM
Last modification on : Wednesday, February 2, 2022 - 3:38:40 AM

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  • HAL Id : inserm-03543894, version 1
  • PUBMED : 16733499

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Elise Glattard, Arnaud Muller, Dominique Aunis, Marie-Hélène Metz-Boutigue, George Stefano, et al.. Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators.. Medical Science Monitor, Medical Science International Publishing, 2006, 12 (6), pp.SR25-7. ⟨inserm-03543894⟩

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