Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
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Arthur Lefevre
- Function : Author
- PersonId : 781934
- ORCID : 0000-0003-2847-0859
- IdRef : 200207636
Diego Benusiglio
- Function : Author
- PersonId : 772936
- ORCID : 0000-0002-6093-1398
Andrei Rozov
- Function : Author
- PersonId : 791425
- ORCID : 0000-0002-4932-4095
Matthew Kirchner
- Function : Author
- PersonId : 803284
- ORCID : 0000-0001-6960-7685
Hong Wang
- Function : Author
- PersonId : 768198
- ORCID : 0000-0003-0058-060X
Perrine Inquimbert
- Function : Author
- PersonId : 756944
- ORCID : 0000-0003-2625-1468
- IdRef : 130289183
Claudia Pitzer
- Function : Author
- PersonId : 801531
- ORCID : 0000-0002-7663-1031
Jan Siemens
- Function : Author
- PersonId : 801532
- ORCID : 0000-0001-9051-9217
Yannick Goumon
- Function : Author
- PersonId : 1066168
Benjamin Boutrel
- Function : Author
- PersonId : 792785
- ORCID : 0000-0003-4988-759X
- IdRef : 188279709
Christophe Maurice Lamy
- Function : Author
- PersonId : 801533
- ORCID : 0000-0001-6944-9787
Nathalie Rouach
- Function : Author
- PersonId : 182459
- IdHAL : nathalie-rouach
- ORCID : 0000-0002-5574-888X
- IdRef : 071365648
W. Scott Young
- Function : Author
- PersonId : 821342
- ORCID : 0000-0001-6614-5112
Valery Grinevich
- Function : Author
- PersonId : 795488
- ORCID : 0000-0002-6337-8866
- IdRef : 233332723
Alexandre Charlet
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- Function : Correspondent author
- PersonId : 176179
- IdHAL : alexandre-charlet
- ORCID : 0000-0003-4837-3706
- IdRef : 142645141
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Abstract
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.