Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents - Archive ouverte HAL Access content directly
Journal Articles Nature Neuroscience Year : 2021

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

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Diego Benusiglio
Matthew Kirchner
Ranjan Roy
Jan Siemens
Benjamin Boutrel
W. Scott Young
Valery Grinevich

Abstract

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.

Dates and versions

inserm-03543734 , version 1 (26-01-2022)

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Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, et al.. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neuroscience, 2021, 24 (4), pp.529-541. ⟨10.1038/s41593-021-00800-0⟩. ⟨inserm-03543734⟩
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