Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents
Jérôme Wahis
(1, 2)
,
Angel Baudon
(1)
,
Ferdinand Althammer
(3)
,
Damien Kerspern
(1)
,
Stéphanie Goyon
(1)
,
Daisuke Hagiwara
(4)
,
Arthur Lefevre
(1, 4)
,
Lara Barteczko
(4)
,
Benjamin Boury-Jamot
(5)
,
Benjamin Bellanger
(1)
,
Marios Abatis
(5)
,
Miriam da Silva Gouveia
(6)
,
Diego Benusiglio
(4)
,
Marina Eliava
(4)
,
Andrei Rozov
(7, 4)
,
Ivan Weinsanto
(1)
,
Hanna Sophie Knobloch-Bollmann
(8, 9)
,
Matthew Kirchner
(3)
,
Ranjan Roy
(3)
,
Hong Wang
(4, 10)
,
Marie Pertin
(5)
,
Perrine Inquimbert
(1)
,
Claudia Pitzer
(11)
,
Jan Siemens
(4)
,
Yannick Goumon
(1)
,
Benjamin Boutrel
(5)
,
Christophe Maurice Lamy
(12)
,
Isabelle Decosterd
(13, 5)
,
Jean-Yves Chatton
(5)
,
Nathalie Rouach
(14, 15)
,
W. Scott Young
(16)
,
Javier Stern
(3)
,
Pierrick Poisbeau
(1)
,
Ron Stoop
(5)
,
Pascal Darbon
(1)
,
Valery Grinevich
(4)
,
Alexandre Charlet
(1, 17)
1
INCI -
Institut des Neurosciences Cellulaires et Intégratives
2 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
3 Georgia State University
4 Universität Heidelberg [Heidelberg] = Heidelberg University
5 Lausanne University Hospital
6 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
7 KFU - Kazan Federal University
8 Harvard University [Cambridge]
9 University of Freiburg [Freiburg]
10 SIAT - Shenzhen Institutes of Advanced Technology
11 Ruprecht Karls Universitat Heidelberg [Baden-Württemberg, Germany]
12 UNIGE - Université de Genève = University of Geneva
13 UNIL - Université de Lausanne = University of Lausanne
14 CIRB - Centre interdisciplinaire de recherche en biologie
15 Labex MemoLife
16 NIMH - National Institute of Mental Health
17 USIAS - Institut d’Etudes Avancées de l’Université de Strasbourg - Institute for Advanced Study
2 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
3 Georgia State University
4 Universität Heidelberg [Heidelberg] = Heidelberg University
5 Lausanne University Hospital
6 Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
7 KFU - Kazan Federal University
8 Harvard University [Cambridge]
9 University of Freiburg [Freiburg]
10 SIAT - Shenzhen Institutes of Advanced Technology
11 Ruprecht Karls Universitat Heidelberg [Baden-Württemberg, Germany]
12 UNIGE - Université de Genève = University of Geneva
13 UNIL - Université de Lausanne = University of Lausanne
14 CIRB - Centre interdisciplinaire de recherche en biologie
15 Labex MemoLife
16 NIMH - National Institute of Mental Health
17 USIAS - Institut d’Etudes Avancées de l’Université de Strasbourg - Institute for Advanced Study
Arthur Lefevre
- Function : Author
- PersonId : 781934
- ORCID : 0000-0003-2847-0859
- IdRef : 200207636
Diego Benusiglio
- Function : Author
- PersonId : 772936
- ORCID : 0000-0002-6093-1398
Andrei Rozov
- Function : Author
- PersonId : 791425
- ORCID : 0000-0002-4932-4095
Matthew Kirchner
- Function : Author
- PersonId : 803284
- ORCID : 0000-0001-6960-7685
Hong Wang
- Function : Author
- PersonId : 768198
- ORCID : 0000-0003-0058-060X
Perrine Inquimbert
- Function : Author
- PersonId : 756944
- ORCID : 0000-0003-2625-1468
- IdRef : 130289183
Claudia Pitzer
- Function : Author
- PersonId : 801531
- ORCID : 0000-0002-7663-1031
Jan Siemens
- Function : Author
- PersonId : 801532
- ORCID : 0000-0001-9051-9217
Yannick Goumon
- Function : Author
- PersonId : 1066168
Benjamin Boutrel
- Function : Author
- PersonId : 792785
- ORCID : 0000-0003-4988-759X
- IdRef : 188279709
Christophe Maurice Lamy
- Function : Author
- PersonId : 801533
- ORCID : 0000-0001-6944-9787
Nathalie Rouach
- Function : Author
- PersonId : 182459
- IdHAL : nathalie-rouach
- ORCID : 0000-0002-5574-888X
- IdRef : 071365648
W. Scott Young
- Function : Author
- PersonId : 821342
- ORCID : 0000-0001-6614-5112
Valery Grinevich
- Function : Author
- PersonId : 795488
- ORCID : 0000-0002-6337-8866
- IdRef : 233332723
Alexandre Charlet
Connectez-vous pour contacter l'auteur
- Function : Correspondent author
- PersonId : 176179
- IdHAL : alexandre-charlet
- ORCID : 0000-0003-4837-3706
- IdRef : 142645141
Connectez-vous pour contacter l'auteur
Abstract
Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.