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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Jérôme Wahis 1, 2 Angel Baudon 1 Ferdinand Althammer 3 Damien Kerspern 1 Stéphanie Goyon 1 Daisuke Hagiwara 4 Arthur Lefevre 1, 4 Lara Barteczko 4 Benjamin Boury-Jamot 5 Benjamin Bellanger 1 Marios Abatis 5 Miriam da Silva Gouveia 6 Diego Benusiglio 4 Marina Eliava 4 Andrei Rozov 7, 4 Ivan Weinsanto 1 Hanna Sophie Knobloch-Bollmann 8, 9 Matthew Kirchner 3 Ranjan Roy 3 Hong Wang 4, 10 Marie Pertin 5 Perrine Inquimbert 1 Claudia Pitzer 11 Jan Siemens 4 yannick Goumon 1 Benjamin Boutrel 5 Christophe Maurice Lamy 12 Isabelle Decosterd 13, 5 Jean-yves Chatton 5 Nathalie Rouach 14, 15 W. Scott young 16 Javier Stern 3 Pierrick Poisbeau 1 Ron Stoop 5 Pascal Darbon 1 Valery Grinevich 4 Alexandre Charlet 1, 17, * 
Abstract : Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.
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https://www.hal.inserm.fr/inserm-03543734
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Submitted on : Wednesday, January 26, 2022 - 11:16:53 AM
Last modification on : Friday, April 1, 2022 - 3:57:59 AM

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Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, et al.. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neuroscience, Nature Publishing Group, 2021, 24 (4), pp.529-541. ⟨10.1038/s41593-021-00800-0⟩. ⟨inserm-03543734⟩

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