Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Jérôme Wahis; Angel Baudon; Ferdinand Althammer; Damien Kerspern; Stéphanie Goyon; Daisuke Hagiwara; Arthur Lefevre; Lara Barteczko; Benjamin Boury-Jamot; Benjamin Bellanger; Marios Abatis; Miriam da Silva Gouveia; Diego Benusiglio; Marina Eliava; Andrei Rozov; Ivan Weinsanto; Hanna Sophie Knobloch-Bollmann; Matthew Kirchner; Ranjan Roy; Hong Wang; Marie Pertin; Perrine Inquimbert; Claudia Pitzer; Jan Siemens; Yannick Goumon; Benjamin Boutrel; Christophe Maurice Lamy; Isabelle Decosterd; Jean-Yves Chatton; Nathalie Rouach; W. Scott Young; Javier Stern; Pierrick Poisbeau; Ron Stoop; Pascal Darbon; Valery Grinevich; Alexandre Charlet

doi:10.1038/s41593-021-00800-0

Journal Articles Nature Neuroscience Year : 2021

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

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Jérôme Wahis

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Catholic University of Leuven - Katholieke Universiteit Leuven

Angel Baudon

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Ferdinand Althammer

Function : Author

Georgia State University

Damien Kerspern

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Stéphanie Goyon

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Daisuke Hagiwara

Function : Author

Universität Heidelberg [Heidelberg]

Arthur Lefevre

Function : Author
PersonId : 781934
ORCID : 0000-0003-2847-0859
IdRef : 200207636

Institut des Neurosciences Cellulaires et Intégratives

Universität Heidelberg [Heidelberg]

Lara Barteczko

Function : Author

Universität Heidelberg [Heidelberg]

Benjamin Boury-Jamot

Function : Author

Lausanne University Hospital

Benjamin Bellanger

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Marios Abatis

Function : Author

Lausanne University Hospital

Miriam da Silva Gouveia

Function : Author

Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)

Diego Benusiglio

Function : Author
PersonId : 772936
ORCID : 0000-0002-6093-1398

Universität Heidelberg [Heidelberg]

Marina Eliava

Function : Author

Universität Heidelberg [Heidelberg]

Andrei Rozov

Function : Author
PersonId : 791425
ORCID : 0000-0002-4932-4095

Kazan Federal University

Universität Heidelberg [Heidelberg]

Ivan Weinsanto

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Hanna Sophie Knobloch-Bollmann

Function : Author

Harvard University [Cambridge]

University of Freiburg [Freiburg]

Matthew Kirchner

Function : Author
PersonId : 803284
ORCID : 0000-0001-6960-7685

Georgia State University

Ranjan Roy

Function : Author
PersonId : 803285
ORCID : 0000-0001-6234-8043

Georgia State University

Hong Wang

Function : Author
PersonId : 768198
ORCID : 0000-0003-0058-060X

Universität Heidelberg [Heidelberg]

Shenzhen Institutes of Advanced Technology

Marie Pertin

Function : Author

Lausanne University Hospital

Perrine Inquimbert

Function : Author
PersonId : 756944
ORCID : 0000-0003-2625-1468
IdRef : 130289183

Institut des Neurosciences Cellulaires et Intégratives

Claudia Pitzer

Function : Author
PersonId : 801531
ORCID : 0000-0002-7663-1031

Ruprecht Karls Universitat Heidelberg [Baden-Württemberg, Germany]

Jan Siemens

Function : Author
PersonId : 801532
ORCID : 0000-0001-9051-9217

Universität Heidelberg [Heidelberg]

Yannick Goumon

Function : Author
PersonId : 1066168

Institut des Neurosciences Cellulaires et Intégratives

Benjamin Boutrel

Function : Author
PersonId : 792785
ORCID : 0000-0003-4988-759X
IdRef : 188279709

Lausanne University Hospital

Christophe Maurice Lamy

Function : Author
PersonId : 801533
ORCID : 0000-0001-6944-9787

Université de Genève = University of Geneva

Isabelle Decosterd

Function : Author

Université de Lausanne = University of Lausanne

Lausanne University Hospital

Jean-Yves Chatton

Function : Author

Lausanne University Hospital

Nathalie Rouach

Function : Author
PersonId : 182459
IdHAL : nathalie-rouach
ORCID : 0000-0002-5574-888X
IdRef : 071365648

Centre interdisciplinaire de recherche en biologie

Labex MemoLife

W. Scott Young

Function : Author
PersonId : 821342
ORCID : 0000-0001-6614-5112

National Institute of Mental Health

Javier Stern

Function : Author

Georgia State University

Pierrick Poisbeau

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Ron Stoop

Function : Author

Lausanne University Hospital

Pascal Darbon

Function : Author

Institut des Neurosciences Cellulaires et Intégratives

Valery Grinevich

Function : Author
PersonId : 795488
ORCID : 0000-0002-6337-8866
IdRef : 233332723

Universität Heidelberg [Heidelberg]

Alexandre Charlet

Function : Correspondent author
PersonId : 176179
IdHAL : alexandre-charlet
ORCID : 0000-0003-4837-3706
IdRef : 142645141

Connectez-vous pour contacter l'auteur

Institut des Neurosciences Cellulaires et Intégratives

Institut d’Etudes Avancées de l’Université de Strasbourg - Institute for Advanced Study

Abstract

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function and pharmacological approaches, we demonstrate that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. The involvement of astrocytes in OT signaling challenges the long-held dogma that OT acts exclusively on neurons and highlights astrocytes as essential components for modulation of emotional states under normal and chronic pain conditions.

Domains

Cognitive science

Yannick Goumon : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-03543734

Submitted on : Wednesday, January 26, 2022-11:16:53 AM

Last modification on : Tuesday, October 18, 2022-4:30:04 AM

Dates and versions

inserm-03543734 , version 1 (26-01-2022)

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HAL Id : inserm-03543734 , version 1
DOI : 10.1038/s41593-021-00800-0
PUBMED : 33589833

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Jérôme Wahis, Angel Baudon, Ferdinand Althammer, Damien Kerspern, Stéphanie Goyon, et al.. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nature Neuroscience, 2021, 24 (4), pp.529-541. ⟨10.1038/s41593-021-00800-0⟩. ⟨inserm-03543734⟩

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Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

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