Skip to Main content Skip to Navigation
Journal articles

Function of Centriolar Satellites and Regulation by Post-Translational Modifications

Clotilde Renaud 1 Nicolas Bidère 1 
1 CRCINA-ÉQUIPE 15 - Signaling in Oncogenesis, Angiogenesis and Permeability
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Centriolar satellites are small membrane-less granules that gravitate around the centrosome. Recent advances in defining the satellite proteome and interactome have unveiled hundreds of new satellite components thus illustrating the complex nature of these particles. Although initially linked to the homeostasis of centrosome and the formation of primary cilia, these composite and highly dynamic structures appear to participate in additional cellular processes, such as proteostasis, autophagy, and cellular stress. In this review, we first outline the main features and many roles of centriolar satellites. We then discuss how post-translational modifications, such as phosphorylation and ubiquitination, shape their composition and functions. This is of particular interest as interfering with these processes may provide ways to manipulate these structures.
Document type :
Journal articles
Complete list of metadata
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Monday, January 24, 2022 - 12:03:24 PM
Last modification on : Wednesday, April 27, 2022 - 4:29:27 AM
Long-term archiving on: : Monday, April 25, 2022 - 6:51:35 PM


Publisher files allowed on an open archive



Clotilde Renaud, Nicolas Bidère. Function of Centriolar Satellites and Regulation by Post-Translational Modifications. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.780502. ⟨10.3389/fcell.2021.780502⟩. ⟨inserm-03540899⟩



Record views


Files downloads