Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study
Sabine Kayser
(1)
,
Richard Schlenk
(2)
,
Delphine Lebon
(3)
,
Martin Carre
(4)
,
Katharina Götze
(5)
,
Friedrich Stölzel
(6)
,
Ana Berceanu
(7)
,
Kerstin Schäfer-Eckart
(8)
,
Pierre Peterlin
(9)
,
Yosr Hicheri
(10)
,
Ramy Rahme
(11, 12)
,
Emmanuel Raffoux
(11, 12)
,
Fatiha Chermat
(11, 12)
,
Stefan Krause
(13)
,
Walter Aulitzky
(14)
,
Sophie Rigaudeau
(15)
,
Richard Noppeney
(16)
,
Celine Berthon
(17)
,
Martin Görner
(18)
,
Edgar Jost
(19)
,
Philippe Carassou
(20)
,
Ulrich Keller
(21)
,
Corentin Orvain
(22, 23, 24)
,
Thorsten Braun
(25, 26)
,
Colombe Saillard
(27)
,
Ali Arar
(28)
,
Volker Kunzmann
(29)
,
Mathieu Wemeau
(30)
,
Maike de Wit
(31)
,
Dirk Niemann
(32)
,
Caroline Bonmati
(33)
,
Carsten Schwänen
(34)
,
Julie Abraham
(35)
,
Ahmad Aljijakli
(36)
,
Stephanie Haiat
(37)
,
Alwin Krämer
(38)
,
Albrecht Reichle
(39)
,
Martina Gnadler
(40)
,
Christophe Willekens
(41, 42)
,
Karsten Spiekermann
(43)
,
Wolfgang Hiddemann
(43)
,
Carsten Müller-Tidow
(44)
,
Christian Thiede
(45)
,
Christoph Röllig
(45)
,
Hubert Serve
(46)
,
Martin Bornhäuser
(45)
,
Claudia Baldus
(47)
,
Eva Lengfelder
(48)
,
Pierre Fenaux
(11, 12)
,
Uwe Platzbecker
(49)
,
Lionel Adès
(11, 12)
1
DKFZ -
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
2 Heidelberg University Hospital [Heidelberg]
3 CHU Amiens-Picardie
4 CHU - Centre Hospitalier Universitaire [Grenoble]
5 TUM - Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne]
6 University Hospital Carl Gustav Carus [Dresden, Germany]
7 Hôpital JeanMinjoz
8 Klinikum Nürnberg Nord
9 Hôtel-Dieu de Nantes
10 CHRU Montpellier - Hôpital Saint Eloi
11 AP-HP - Hopital Saint-Louis [AP-HP]
12 UPD7 - Université Paris Diderot - Paris 7
13 University Hospital Erlangen = Uniklinikum Erlangen
14 Robert Bosch Gmbh [Schwieberdingen]
15 CHV - Centre Hospitalier de Versailles André Mignot
16 University Hospital [Essen, Germany]
17 Hôpital Claude Huriez [Lille]
18 KB - Klinikum Bielefeld [Bielefeld, Germany]
19 UKA - Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]
20 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
21 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
22 CRCINA-ÉQUIPE 7 - Innate Immunity and Immunotherapy
23 CHU Angers - Centre Hospitalier Universitaire d'Angers
24 FHU GOAL - Fédérations hospitalo-universitaires Grand Ouest Acute Leukemia [Angers]
25 Hôpital Avicenne [AP-HP]
26 UPCité - Université Paris Cité
27 Institut Paoli-Calmettes
28 CHRO - Centre Hospitalier Régional d'Orléans
29 University Hospital of Würzburg
30 Hôpital Provo
31 VKN - Vivantes Klinikum Neukölln [Berlin, Germany]
32 Gemeinschaftsklinikum Mittelrhein gGmbH [Koblenz, Germany]
33 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
34 Ortenau Klinikum Offenburg-Kehl [Offenburg, Germany]
35 Hôpital Dupuytren [CHU Limoges]
36 Centre Hospitalier Victor Dupouy
37 CH Sud Francilien - Centre Hospitalier Sud Francilien [Corbeil-Essonnes]
38 Universität Heidelberg [Heidelberg] = Heidelberg University
39 University Hospital Regensburg
40 St Vincentius Hospital
41 IGR - Institut Gustave Roussy
42 Dynamo - Dynamique moléculaire de la transformation hématopoïétique
43 LMU - Ludwig-Maximilians-Universität München
44 UniversitätsKlinikum Heidelberg
45 TU Dresden - Technische Universität Dresden = Dresden University of Technology
46 Universitätsklinikum Frankfurt am Main [Germany]
47 Kiel University
48 Universität Mannheim [Mannheim]
49 University Hospital Leipzig
2 Heidelberg University Hospital [Heidelberg]
3 CHU Amiens-Picardie
4 CHU - Centre Hospitalier Universitaire [Grenoble]
5 TUM - Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne]
6 University Hospital Carl Gustav Carus [Dresden, Germany]
7 Hôpital JeanMinjoz
8 Klinikum Nürnberg Nord
9 Hôtel-Dieu de Nantes
10 CHRU Montpellier - Hôpital Saint Eloi
11 AP-HP - Hopital Saint-Louis [AP-HP]
12 UPD7 - Université Paris Diderot - Paris 7
13 University Hospital Erlangen = Uniklinikum Erlangen
14 Robert Bosch Gmbh [Schwieberdingen]
15 CHV - Centre Hospitalier de Versailles André Mignot
16 University Hospital [Essen, Germany]
17 Hôpital Claude Huriez [Lille]
18 KB - Klinikum Bielefeld [Bielefeld, Germany]
19 UKA - Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany]
20 CHR Metz-Thionville - Centre hospitalier régional Metz-Thionville
21 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
22 CRCINA-ÉQUIPE 7 - Innate Immunity and Immunotherapy
23 CHU Angers - Centre Hospitalier Universitaire d'Angers
24 FHU GOAL - Fédérations hospitalo-universitaires Grand Ouest Acute Leukemia [Angers]
25 Hôpital Avicenne [AP-HP]
26 UPCité - Université Paris Cité
27 Institut Paoli-Calmettes
28 CHRO - Centre Hospitalier Régional d'Orléans
29 University Hospital of Würzburg
30 Hôpital Provo
31 VKN - Vivantes Klinikum Neukölln [Berlin, Germany]
32 Gemeinschaftsklinikum Mittelrhein gGmbH [Koblenz, Germany]
33 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
34 Ortenau Klinikum Offenburg-Kehl [Offenburg, Germany]
35 Hôpital Dupuytren [CHU Limoges]
36 Centre Hospitalier Victor Dupouy
37 CH Sud Francilien - Centre Hospitalier Sud Francilien [Corbeil-Essonnes]
38 Universität Heidelberg [Heidelberg] = Heidelberg University
39 University Hospital Regensburg
40 St Vincentius Hospital
41 IGR - Institut Gustave Roussy
42 Dynamo - Dynamique moléculaire de la transformation hématopoïétique
43 LMU - Ludwig-Maximilians-Universität München
44 UniversitätsKlinikum Heidelberg
45 TU Dresden - Technische Universität Dresden = Dresden University of Technology
46 Universitätsklinikum Frankfurt am Main [Germany]
47 Kiel University
48 Universität Mannheim [Mannheim]
49 University Hospital Leipzig
Delphine Lebon
- Function : Author
- PersonId : 1151789
- ORCID : 0000-0002-4073-1559
- IdRef : 182804038
Pierre Peterlin
- Function : Author
- PersonId : 776625
- ORCID : 0000-0001-5463-6686
Celine Berthon
- Function : Author
- PersonId : 767888
- ORCID : 0000-0002-3474-2577
Corentin Orvain
- Function : Author
- PersonId : 775693
- ORCID : 0000-0002-8717-0824
Lionel Adès
- Function : Author
- PersonId : 762488
- ORCID : 0000-0002-9020-8766
Abstract
The aim of this study was to characterize a large series of 154 patients with acute promyelocytic leukemia (APL; median age, 53 years; range, 18-90 years) and evaluate real-life outcome after up-front treatment with arsenic trioxide (ATO) and alltrans retinoic acid (ATRA). All patients were included in the prospective NAPOLEON registry (NCT02192619) between 2013 and 2019. APL was de novo in 91% (n=140) and therapy-related in 9% (n=14); 13% (n=20) were older than 70 years. At diagnosis bleeding/hemorrhage was present in 38% and thrombosis in 3%. Complete remission was achieved in 152 patients (99%), whereas two patients (1%) experienced induction death within 18 days after start of therapy. With a median follow-up of 1.99 years (95%-CI, 1.61-2.30 years) 1-year and 2-years overall survival (OS) rates were 97% (95%-CI, 94-100%) and 95% (95%-CI, 91-99%), respectively. Age above 70 years was associated with a significantly shorter OS (P<0.001) as compared to younger patients. So far no relapses were observed. Six patients (4%) died in CR after in median 0.95 years after diagnosis (range, 0.18-2.38 years). Our data confirm the efficiency and durability of ATO/ATRA in the primary management of adult low-/ intermediate-risk APL patients in the real life setting, irrespective of age.
Domains
Cancer
Origin : Publication funded by an institution