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Circulating tumor cells and ctDNA in sarcomas

Abstract : Sarcomas are clustered in two oncological entities named bone and soft-tissue sarcomas. Both are rare cancers originating from the mesenchyme, characterized by their propensity to induce the development of lung metastases. Sarcoma cells escaping from the primary tumor site, spread to the pulmonary tissue through the bloodstream where they found a favorable microenvironment to establish metastatic foci. The low number of patients, the high histological, genetic and molecular heterogeneity of sarcomas combined with the absence of specific markers expressed by cancer cells make the detection and follow up of the minimal residual disease challenging. Over the last decade, tremendous technological progress has been made towards the detection of recurrent diseases. The literature is now enriched of information describing the use of liquid biopsies in clinical care of sarcoma patients. The present chapter aims to give a brief overview of the most recent data available on the detection of circulating tumor cells and circulating tumor DNA in sarcomas.
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Contributor : Dominique Heymann Connect in order to contact the contributor
Submitted on : Friday, January 21, 2022 - 2:02:49 PM
Last modification on : Wednesday, April 27, 2022 - 4:59:49 AM
Long-term archiving on: : Friday, April 22, 2022 - 7:23:13 PM


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  • HAL Id : inserm-03539019, version 1



Dominique Heymann, Camille Jubelin, Denis Cochonneau, Emilie Moranton, Javier Muñoz-Garcia. Circulating tumor cells and ctDNA in sarcomas. Cancer Metastasis Through the Lymphovascular System, In press. ⟨inserm-03539019⟩



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