Skip to Main content Skip to Navigation
Journal articles

The E protein-TCF1 axis controls γδ T cell development and effector fate

Abstract : TCF1 plays a critical role in T lineage commitment and the development of αβ lineage T cells, but its role in γδ T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory element in the Tcf7 locus, and this axis regulates both γδ T lineage commitment and effector fate. Indeed, the level of TCF1 expression plays an important role in setting the threshold for γδ T lineage commitment and modulates the ability of TCR signaling to influence effector fate adoption by γδ T lineage progenitors. This finding provides mechanistic insight into how TCR-mediated repression of E proteins promotes the development of γδ T cells and their adoption of the interleukin (IL)-17-producing effector fate. IL-17-producing γδ T cells have been implicated in cancer progression and in the pathogenesis of psoriasis and multiple sclerosis.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03538823
Contributor : HARLY CHRISTELLE Connect in order to contact the contributor
Submitted on : Friday, January 21, 2022 - 12:01:05 PM
Last modification on : Tuesday, May 3, 2022 - 3:14:04 PM
Long-term archiving on: : Friday, April 22, 2022 - 7:12:58 PM

File

PIIS2211124721000292.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Shawn Fahl, Alejandra Contreras, Anjali Verma, Xiang Qiu, Christelle Harly, et al.. The E protein-TCF1 axis controls γδ T cell development and effector fate. Cell Reports, Elsevier Inc, 2021, 34 (5), pp.108716. ⟨10.1016/j.celrep.2021.108716⟩. ⟨inserm-03538823⟩

Share

Metrics

Record views

11

Files downloads

7