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Journal Articles Nature Immunology Year : 2015

TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow

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Abstract

The cellular and molecular events that drive the early development of innate lymphoid cells (ILCs) remain poorly understood. We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors. Using novel reporter mice, we identified a new subset of early ILC progenitors (EILPs) expressing high amounts of TCF-1. EILPs lacked efficient T and B lymphocyte potential but efficiently gave rise to NK cells and all known adult helper ILC lineages, indicating that they are the earliest ILC-committed progenitors identified so far. Our results suggest that upregulation of TCF-1 expression denotes the earliest stage of ILC fate specification. The discovery of EILPs provides a basis for deciphering additional signals that specify ILC fate.

Dates and versions

inserm-03538018 , version 1 (20-01-2022)

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Qi Yang, Fengyin Li, Christelle Harly, Shaojun Xing, Longyun Ye, et al.. TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nature Immunology, 2015, 16 (10), pp.1044-1050. ⟨10.1038/ni.3248⟩. ⟨inserm-03538018⟩
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