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Journal Articles Sleep Medicine Year : 2021

Beclin-1 increases with obstructive sleep apnea severity

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Abstract

Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis.
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inserm-03534484 , version 1 (19-01-2022)

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Frédéric Schlemmer, Maéva Zysman, Bruno Ribeiro Baptista, Etienne Audureau, Ala Covali Noroc, et al.. Beclin-1 increases with obstructive sleep apnea severity. Sleep Medicine, 2021, 81, pp.474-476. ⟨10.1016/j.sleep.2021.03.017⟩. ⟨inserm-03534484⟩

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