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Beclin-1 increases with obstructive sleep apnea severity

Abstract : Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis.
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Submitted on : Wednesday, January 19, 2022 - 2:34:17 PM
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Frédéric Schlemmer, Maéva Zysman, Bruno Ribeiro Baptista, Etienne Audureau, Ala Covali Noroc, et al.. Beclin-1 increases with obstructive sleep apnea severity. Sleep Medicine, Elsevier, 2021, 81, pp.474-476. ⟨10.1016/j.sleep.2021.03.017⟩. ⟨inserm-03534484⟩



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