Skip to Main content Skip to Navigation
Journal articles

Molecular and epidemiological characterization of recurrent Mycobacterium ulcerans infections in Benin

Abstract : Background: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans, an environmental mycobacterium. Although transmission of M. ulcerans remains poorly understood, the main identified risk factor for acquiring Buruli ulcer is living in proximity of potentially contaminated water sources. Knowledge about the clinical features of Buruli ulcer and its physiopathology is increasing, but little is known about recurrence due to reinfection. Methodology/principal findings: We describe two patients with Buruli ulcer recurrence due to reinfection with M. ulcerans, as demonstrated by comparisons of DNA from the strains isolated at the time of the first diagnosis and at recurrence. Based on the spatial distribution of M. ulcerans genotypes in this region and a detailed study of the behavior of these two patients with respect to sources of water as well as water bodies and streams, we formulated hypotheses concerning the sites at which they may have been contaminated. Conclusions/significance: Second episodes of Buruli ulcer may occur through reinfection, relapse or a paradoxical reaction. We formally demonstrated that the recurrence in these two patients was due to reinfection. Based on the sites at which the patients reported engaging in activities relating to water, we were able to identify possible sites of contamination. Our findings indicate that the non-random distribution of M. ulcerans genotypes in this region may provide useful information about activities at risk.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03531913
Contributor : Christine Dupuis Connect in order to contact the contributor
Submitted on : Tuesday, January 18, 2022 - 1:42:28 PM
Last modification on : Friday, August 5, 2022 - 10:44:42 AM

File

journal.pntd.0010053.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Ronald Gnimavo, Alban Besnard, Horace Degnonvi, Juliana Pipoli da Fonseca, Marie Kempf, et al.. Molecular and epidemiological characterization of recurrent Mycobacterium ulcerans infections in Benin. PLoS Neglected Tropical Diseases, Public Library of Science, 2021, 15 (12), pp.e0010053. ⟨10.1371/journal.pntd.0010053⟩. ⟨inserm-03531913⟩

Share

Metrics

Record views

47

Files downloads

43