Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration

Abstract : Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and regenerative functions of satellite cells. We show that conditional deletion of the Chd4 gene in satellite cells results in failure to regenerate muscle after injury. This defect is principally associated with increased stem cell plasticity and lineage infidelity during the expansion of satellite cells, caused by de-repression of non-muscle-cell lineage genes in the absence of Chd4. Thus, CHD4 ensures that a transcriptional program that safeguards satellite cell identity during muscle regeneration is maintained. Given the therapeutic potential of muscle stem cells in diverse neuromuscular pathologies, CHD4 constitutes an attractive target for satellite cell-based therapies.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03528093
Contributor : Sylvie DUFOUR Connect in order to contact the contributor
Submitted on : Monday, January 17, 2022 - 9:31:52 AM
Last modification on : Thursday, April 21, 2022 - 3:57:51 PM
Long-term archiving on: : Monday, April 18, 2022 - 6:21:15 PM

File

1-s2.0-S221367112100388X-main....
Publication funded by an institution

Identifiers

Collections

Citation

Krishnamoorthy Sreenivasan, Alejandra Rodríguez-Delarosa, Johnny Kim, Diana Mesquita, Jessica Segalés, et al.. CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration. Stem Cell Reports, Elsevier, 2021, 16 (9), pp.2089-2098. ⟨10.1016/j.stemcr.2021.07.022⟩. ⟨inserm-03528093⟩

Share

Metrics

Record views

10

Files downloads

12