Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases - Archive ouverte HAL Access content directly
Journal Articles Biomedicines Year : 2020

Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases

(1, 2, 3) , (4, 1, 2) , (1, 2) , (5, 1, 2) , (4, 1, 2) , (1, 2) , (6) , (6) , (4, 1, 2, 6) , (7) , (4, 1, 2, 6) , (5, 1, 2)
1
2
3
4
5
6
7

Abstract

Background: Stereotactic body radiotherapy (SBRT) for vertebral metastases (VM) allows the delivery of high radiation doses to tumors while sparing the spinal cord. We report a new approach to clinical target volume (CTV) delineation based on anti-carcinoembryonic antigen (CEA) positron emission tomography (pretargeted immuno-PET; “iPET”) in patients with metastatic breast cancer (BC) or medullary thyroid cancer (MTC). Methods: All patients underwent iPET, spine magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT) using 18F-deoxyglucose (FDG) for BC or 18F-dihydroxy-phenylalanine (F-DOPA) for MTC. Vertebrae locations and vertebral segments of lesions were recorded and the impact on CTV delineation was evaluated. Results: Forty-six VM eligible for SBRT following iPET were evaluated in eight patients (five BC, three MTC). Eighty-one vertebral segments were detected using MRI, 26 with FDG or F-DOPA PET/CT, and 70 using iPET. iPET was able to detect more lesions than MRI for vertebral bodies (44 vs. 34). iPET-based delineation modified MRI-based CTV in 70% (32/46) of cases. Conclusion: iPET allows a precise mapping of affected VM segments, and adds complementary information to MRI in the definition of candidate volumes for VM SBRT. iPET may facilitate determining target volumes for treatment with stereotactic body radiotherapy in metastatic vertebral disease.
Fichier principal
Vignette du fichier
biomedicines-08-00548-v2.pdf (1.71 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

inserm-03500271 , version 1 (22-12-2021)

Identifiers

Cite

Baptiste Pichon, Caroline Rousseau, Audrey Blanc-Lapierre, Gregory Delpon, Ludovic Ferrer, et al.. Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases. Biomedicines, 2020, 8 (12), pp.548. ⟨10.3390/biomedicines8120548⟩. ⟨inserm-03500271⟩
19 View
65 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More