A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia - Archive ouverte HAL Access content directly
Journal Articles Cancer Medicine Year : 2021

A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia

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Pierre Peterlin
  • Function : Correspondent author
  • PersonId : 1042071

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Joelle Gaschet
  • Function : Author
Michel Cherel
Benoît Tessoulin

Abstract

The aim of this study was to assess the potential impact of the kinetics of serum levels of seven cytokines during induction in acute myeloid leukemia (AML) patients. Indeed, the role of cytokines, in the pathophysiology and response to therapy of AML patients, remains under investigation. Here, we report on the impact of peripheral levels of two cytokines, the Fms-like tyrosine kinase 3 ligand (FL) and interleukin-6 (IL-6), evaluated during first-line intensive induction. A new risk stratification can be proposed, which supersedes the ELN 2017 classification to predict survivals in AML patients by examining the kinetic profile of these cytokines during the induction phase. It segregates three groups of, respectively, high-risk, characterized by a stagnation of low FL levels, intermediate risk, with dynamic increasing FL levels and high IL-6 at day 22, and favorable risk with increasing FL levels but low IL-6 at day 22.
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Origin : Publication funded by an institution

Dates and versions

inserm-03495750 , version 1 (20-12-2021)

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Pierre Peterlin, Joelle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, et al.. A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Medicine, 2021, 10 (2), pp.642-648. ⟨10.1002/cam4.3648⟩. ⟨inserm-03495750⟩
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