Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, EpiSciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Role of growth hormone in hepatic and intestinal triglyceride-rich lipoprotein metabolism

Abstract : Background: Elevated plasma concentrations of hepatic- and intestinally-derived triglyceride-rich lipoproteins (TRL) are implicated in the pathogenesis of atherosclerotic cardiovascular disease and all-cause mortality. Excess of TRL is the driving cause of atherogenic dyslipidemia commonly occurring in insulin-resistant individuals such as patients with obesity, type 2 diabetes and metabolic syndrome. Interestingly, growth hormone (GH)-deficient individuals display similar atherogenic dyslipidemia, suggesting an important role of GH and GH deficiency in the regulation of TRL metabolism. Objective: We aimed to examine the direct and/or indirect role of GH on TRL metabolism. Methods: We investigated the effect on fasting and postprandial hepatic-TRL and intestinal-TRL metabolism of short-term (one month) withdrawal of GH in 10 GH-deficient adults. Results: After GH withdrawal, we found a reduction in fasting plasma TRL concentration (significant decrease in TRL-TG, TRL-cholesterol, TRL-apoB-100, TRL-apoC-III and TRL-apoC-II) but not in postprandial TRL response. This reduction was due to fewer fasting TRL particles without a change in TG per particle and was not accompanied by a change in postprandial TRL-apoB-48 response. Individual reductions in TRL correlated strongly with increases in insulin sensitivity and decreases in TRL-apoC-III. Conclusion: In this relatively short term 'loss of function' human experimental model, we have shown an unanticipated reduction of hepatic-TRL particles despite increase in total body fat mass and reduction in lean mass. These findings contrast with the atherogenic dyslipidemia previously described in chronic GH deficient states, providing a new perspective for the role of GH in lipoprotein metabolism.
Document type :
Journal articles
Complete list of metadata
Contributor : Odile Malbec Connect in order to contact the contributor
Submitted on : Wednesday, December 1, 2021 - 3:50:09 PM
Last modification on : Sunday, June 26, 2022 - 5:58:42 AM
Long-term archiving on: : Wednesday, March 2, 2022 - 7:51:20 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Marie Maraninchi, Anastasia Calabrese, Juan-Patricio Nogueira, Frédéric Castinetti, Julien Mancini, et al.. Role of growth hormone in hepatic and intestinal triglyceride-rich lipoprotein metabolism. Journal of clinical lipidology, Elsevier, 2021, S1933-2874 (21), pp.00123-9. ⟨10.1016/j.jacl.2021.08.003⟩. ⟨inserm-03462002⟩



Record views