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Journal Articles Cell Death and Disease Year : 2016

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

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Abstract

Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the β-cell mass mainly through proliferation of pre-existing and newly formed β-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced β-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in β-cells. β-Cell cycling increased by conditional β-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in β-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the β-cell, by modulating its cell cycle and protection from DNA damage.
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Dates and versions

inserm-03455713 , version 1 (29-11-2021)

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S de Groef, D Renmans, Y Cai, G Leuckx, S Roels, et al.. STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage. Cell Death and Disease, 2016, 7 (6), pp.e2272-e2272. ⟨10.1038/cddis.2016.171⟩. ⟨inserm-03455713⟩
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