Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination
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Richard J Maude
- Function : Author
- PersonId : 798341
- ORCID : 0000-0002-5355-0562
Lorenz von Seidlein
- Function : Author
- PersonId : 800617
- ORCID : 0000-0002-0282-6469
François Nosten
- Function : Author
- PersonId : 768753
- ORCID : 0000-0002-7951-0745
- IdRef : 084012633
Tran Minh Nhat
- Function : Author
- PersonId : 816475
- ORCID : 0000-0002-9500-8341
Caroline Buckee
- Function : Author
- PersonId : 808500
- ORCID : 0000-0002-8386-5899
Jordi Landier
- Function : Author
- PersonId : 21070
- IdHAL : jordilandier
- ORCID : 0000-0001-8619-9775
- IdRef : 183054644
James Callery
- Function : Author
- PersonId : 816476
- ORCID : 0000-0002-3218-2166
Podjanee Jittamala
- Function : Author
- PersonId : 812830
- ORCID : 0000-0002-1020-2760
Frank Smithuis
- Function : Author
- PersonId : 795243
- ORCID : 0000-0002-4704-9915
Abul Faiz
- Function : Author
Christina S Hubbart
- Function : Author
- PersonId : 816477
- ORCID : 0000-0001-9576-9581
Richard D Pearson
- Function : Author
- PersonId : 793847
- ORCID : 0000-0002-7386-3566
Kirk Rockett
- Function : Author
- PersonId : 802066
- ORCID : 0000-0002-6369-9299
Nicholas P Day
- Function : Author
- PersonId : 796732
- ORCID : 0000-0003-2309-1171
Arjen M Dondorp
- Function : Author
- PersonId : 795244
- ORCID : 0000-0001-5190-2395
Olivo Miotto
- Function : Author
- PersonId : 770355
- ORCID : 0000-0001-8060-6771
Abstract
Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.
Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.
Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.
Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.
Origin : Publisher files allowed on an open archive