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Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Christopher Jacob 1 Nguyen Thuy-Nhien 2 Mayfong Mayxay 3, 4, 5 Richard Maude 5, 6, 7 Huynh Quang 8 Bouasy Hongvanthong 9 Viengxay Vanisaveth 9 Thang Ngo Duc 10 Huy Rekol 11 Rob van der Pluijm 5, 6 Lorenz von Seidlein 5, 6 Rick Fairhurst 12 François Nosten 5, 13 Md Hossain 14 Naomi Park 1 Scott Goodwin 1 Pascal Ringwald 15 Keobouphaphone Chindavongsa 9 Paul Newton 3, 5, 6 Elizabeth Ashley 3, 5 Sonexay Phalivong 3 Rapeephan Maude 6 Rithea Leang 11 Cheah Huch 11 Le Dong 16 Kim-Tuyen Nguyen 2 Tran Nhat 2 Tran Hien 2 Hoa Nguyen 17 Nicole Zdrojewski 17 Sara Canavati 17 Abdullah Sayeed 14 Didar Uddin 6 Caroline Buckee 7 Caterina Fanello 5, 6 Marie Onyamboko 18 Thomas Peto 5, 6 Rupam Tripura 5, 6 Chanaki Amaratunga 12 Aung Myint Thu 5, 13 Gilles Delmas 5, 13 Jordi Landier 13, 19 Daniel Parker 13, 20 Nguyen Chau 2 Dysoley Lek 11 Seila Suon 11 James Callery 5, 6 Podjanee Jittamala 6 Borimas Hanboonkunupakarn 6 Sasithon Pukrittayakamee 6, 21 Aung Phyo 5, 22 Frank Smithuis 5, 22 Khin Lin 23 Myo Thant 24 Tin Hlaing 24 Parthasarathi Satpathi 25 Sanghamitra Satpathi 26 Prativa Behera 26 Amar Tripura 27 Subrata Baidya 27 Neena Valecha 28 Anupkumar Anvikar 28 Akhter Ul Islam 29 Abul Faiz Chanon Kunasol 6 Eleanor Drury 30 Mihir Kekre 30 Mozam Ali 30 Katie Love 30 Shavanthi Rajatileka 30 Anna Jeffreys 5 Kate Rowlands 5 Christina Hubbart 5 Mehul Dhorda 5, 6, 31 Ranitha Vongpromek 6, 31 Namfon Kotanan 6 Phrutsamon Wongnak 6 Jacob Almagro Garcia 5 Richard Pearson 30, 5 Cristina Ariani 30 Thanat Chookajorn 6 Cinzia Malangone 30 T Nguyen 30 Jim Stalker 30 Ben Jeffery 5 Jonathan Keatley 30 Kimberly Johnson 30, 5 Dawn Muddyman 30 Xin Chan 5, 6 John Sillitoe 30 Roberto Amato 30 Victoria Simpson 30, 5 Sonia Gonçalves 30 Kirk Rockett 30, 32 Nicholas Day 5, 6 Arjen Dondorp 5, 6 Dominic Kwiatkowski 30, 5 Olivo Miotto 30, 6, 5
1 Wellcome Sanger Institute [Hinxton, Royaume-Uni]
2 OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City]
3 Mahosot Hospital [Vientiane, Laos]
4 Institute of Research and Education Development [Vientiane, Lao People’s Democratic Republic]
5 University of Oxford [Oxford]
6 Mahidol University [Bangkok]
7 Harvard T.H. Chan School of Public Health
8 IMPE - Institute of Malariology, Parasitology, and Entomology [Quy Nhon, Vietnam]
9 CMPE - Centre of Malariology, Parasitology, and Entomology [Vientiane, Lao People’s Democratic Republic]
10 National Institute of Malariology, Parasitology and Entomology [Hanoi]
11 CNM - National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia]
12 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
13 SMRU - Shoklo Malaria Research Unit [Mae Sot, Thailand]
14 CMCH - Chittagong Medical College Hospital [Chittagong, Bangladesh]
15 World Health Organization [Geneva]
16 IMPE - Institute of Malariology, Parasitology, and Entomology [Ho Chi Minh City, Vietnam]
17 VPI - Vysnova Partners Inc [Hanoi, Vietnam]
18 UNIKIN - University of Kinshasa
19 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
20 UCI - University of California [Irvine]
21 Royal Society of Thailand [Bangkok, Thailand]
22 Myanmar Oxford Clinical Research Unit [Yangon, Myanmar]
23 The Department of Medical Research (Upper Myanmar)
24 DSMRC - Defence Services Medical Research Centre [Naypyitaw, Myanmar]
25 MMC - Midnapore Medical College [Midnapur, India]
26 IGH - ispat general hospital [Rourkela, India]
27 AMC - Agartala Medical College [Agartala, India]
28 NIMR - National Institute of Malaria Research [New Dehli, Inde]
29 RUHC - Ramu Upazila Health Complex [Cox’s Bazar, Bangladesh]
30 The Wellcome Trust Sanger Institute [Cambridge]
31 WWARN - WorldWide Antimalarial Resistance Network [Bangkok]
WWARN - WorldWide Antimalarial Resistance Network
32 The Wellcome Trust Centre for Human Genetics [Oxford]
Abstract : Background: National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures. Methods: Samples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs. Results: GenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs. Conclusions: GenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.
Keywords : asia drug resistance epidemiology genetic surveillance global health infectious disease malaria microbiology
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Journal articles
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https://www.hal.inserm.fr/inserm-03451958
Contributor : Odile Malbec Connect in order to contact the contributor
Submitted on : Friday, November 26, 2021 - 4:54:44 PM
Last modification on : Tuesday, November 30, 2021 - 3:38:39 AM

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Christopher Jacob, Nguyen Thuy-Nhien, Mayfong Mayxay, Richard Maude, Huynh Quang, et al.. Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination. eLife, eLife Sciences Publication, 2021, 10, pp.e62997. ⟨10.7554/elife.62997⟩. ⟨inserm-03451958⟩

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