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A guide to ComBat harmonization of imaging biomarkers in multicenter studies

Abstract : The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This "scanner" effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met; thus, ComBat should not be used.
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Submitted on : Monday, November 22, 2021 - 6:19:13 PM
Last modification on : Tuesday, September 27, 2022 - 3:31:11 PM
Long-term archiving on: : Wednesday, February 23, 2022 - 8:35:55 PM


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Fanny Orlhac, Jakoba J Eertink, Anne-Segolene Cottereau, Josee M Zijlstra, Catherine Thieblemont, et al.. A guide to ComBat harmonization of imaging biomarkers in multicenter studies. Journal of Nuclear Medicine, Society of Nuclear Medicine, 2021, pp.jnumed.121.262464. ⟨10.2967/jnumed.121.262464⟩. ⟨inserm-03441717⟩



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