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Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020

Abstract : We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69-V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including S:N501Y in the VOC.
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https://www.hal.inserm.fr/inserm-03412069
Contributor : Julien Marlet Connect in order to contact the contributor
Submitted on : Tuesday, November 2, 2021 - 6:18:08 PM
Last modification on : Tuesday, January 11, 2022 - 5:56:30 PM

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Antonin Bal, Gregory Destras, Alexandre Gaymard, Karl Stefic, Julien Marlet, et al.. Two-step strategy for the identification of SARS-CoV-2 variant of concern 202012/01 and other variants with spike deletion H69–V70, France, August to December 2020. Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (3), pp.2100008. ⟨10.2807/1560-7917.es.2021.26.3.2100008⟩. ⟨inserm-03412069⟩

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