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Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

Abstract : The production of β-lactamases Bla Mab and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from >256 to 16 to 64 g/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.
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https://www.hal.inserm.fr/inserm-03400785
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Submitted on : Monday, October 25, 2021 - 10:42:17 AM
Last modification on : Thursday, April 7, 2022 - 1:58:20 PM
Long-term archiving on: : Wednesday, January 26, 2022 - 7:01:21 PM

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Vincent Dubée Dubée, Daria Soroka, Mélanie Cortes, Anne-Laure Lefebvre, Laurent Gutmann, et al.. Impact of β-Lactamase Inhibition on the Activity of Ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (5), pp.2938 - 2941. ⟨10.1128/aac.05080-14⟩. ⟨inserm-03400785⟩

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