Skip to Main content Skip to Navigation
Journal articles

Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin

Abstract : Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical disease found in rural areas of West and Central Africa. Despite the ongoing efforts to tackle Buruli ulcer epidemics, the environmental reservoir of its pathogen remains elusive, underscoring the need for new approaches to improving disease prevention and management. In our study, we implemented a local-scale spatial clustering model and deciphered the genetic diversity of the bacteria in a small area of Benin where Buruli ulcer is endemic. Using 179 strain samples from West Africa, we conducted a phylogeographic analysis combining whole-genome sequencing with spatial scan statistics. The 8 distinct genotypes we identified were by no means randomly spread over the studied area. Instead, they were divided into 3 different geographic clusters, associated with landscape characteristics. Our results highlight the ability of M. ulcerans to evolve independently and differentially depending on location in a specific ecologic reservoir.
Complete list of metadata

https://www.hal.inserm.fr/inserm-03400720
Contributor : Marie Kempf Connect in order to contact the contributor
Submitted on : Monday, October 25, 2021 - 10:27:37 AM
Last modification on : Wednesday, November 3, 2021 - 10:02:23 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Clément Coudereau, Alban Besnard, Marie Robbe-Saule, Céline Bris, Marie Kempf, et al.. Stable and Local Reservoirs of Mycobacterium ulcerans Inferred from the Nonrandom Distribution of Bacterial Genotypes, Benin. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2020, 26 (3), pp.491 - 503. ⟨10.3201/eid2603.190573⟩. ⟨inserm-03400720⟩

Share

Metrics

Record views

22