Abstract : Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut microbiota has a critical role in pulmonary immunity and host’s defense against viral respiratory infections. The gut microbiota’s composition and function can be profoundly affected in many disease settings, including acute infections, and these changes can aggravate the severity of the disease. Here, we discuss mechanisms by which the gut microbiota arms the lung to control viral respiratory infections. We summarize the impact of viral respiratory infections on the gut microbiota and discuss the potential mechanisms leading to alterations of gut microbiota’s composition and functions. We also discuss the effects of gut microbial imbalance on disease outcomes, including gastrointestinal disorders and secondary bacterial infections. Lastly, we discuss the potential role of the lung–gut axis in coronavirus disease 2019.
https://www.hal.inserm.fr/inserm-03385636 Contributor : François TROTTEINConnect in order to contact the contributor Submitted on : Tuesday, October 19, 2021 - 3:25:41 PM Last modification on : Friday, April 1, 2022 - 3:44:07 AM Long-term archiving on: : Thursday, January 20, 2022 - 7:22:47 PM
Valentin Sencio, Marina Gomes Machado, François Trottein. The lung–gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes. Mucosal Immunology, Nature Pub. Group, 2021, 14 (2), pp.296-304. ⟨10.1038/s41385-020-00361-8⟩. ⟨inserm-03385636⟩