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Glial Purinergic Signaling in Neurodegeneration

Abstract : Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-specific expression patterns of purinergic signaling components change in neurodegeneration and how dysregulated glial purinergic signaling and crosstalk may contribute to disease pathophysiology, thus bearing promising potential for the development of new therapeutical options for neurodegenerative diseases.
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https://www.hal.inserm.fr/inserm-03385134
Contributor : David Blum Connect in order to contact the contributor
Submitted on : Tuesday, October 19, 2021 - 1:28:37 PM
Last modification on : Wednesday, November 10, 2021 - 5:08:03 PM

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Marie Pietrowski, Amr Ahmed Gabr, Stanislav Kozlov, David Blum, Annett Halle, et al.. Glial Purinergic Signaling in Neurodegeneration. Frontiers in Neurology, Frontiers, 2021, 12, pp.654850. ⟨10.3389/fneur.2021.654850⟩. ⟨inserm-03385134⟩

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