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Antigen presentation by mouse monocyte-derived cells: Re-evaluating the concept of monocyte-derived dendritic cells

Abstract : Antigen presentation is a key feature of classical dendritic cells (cDCs). Numerous studies have also reported in mouse that, upon inflammation, monocytes enter tissues and differentiate into monocyte-derived DCs (mo-DC) that have the ability to present antigens to T cells. However, a population of inflammatory cDCs sharing phenotypic features with mo-DC has been recently described, challenging the existence of in vivo-generated mo-DC. Here we review studies describing mouse mo-DC in the light of these findings, and evaluate the in vivo evidence for monocyte-derived antigen-presenting cells. We examine the strategies used to demonstrate the monocytic origin of these cells. Finally, we propose that mo-DC play a complementary role to cDCs, by presenting antigens to effector T cells locally in tissues.
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https://www.hal.inserm.fr/inserm-03381917
Contributor : Elodie Segura Connect in order to contact the contributor
Submitted on : Monday, October 18, 2021 - 9:41:45 AM
Last modification on : Wednesday, November 17, 2021 - 12:33:45 PM

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Elodie Segura, Alice Coillard. Antigen presentation by mouse monocyte-derived cells: Re-evaluating the concept of monocyte-derived dendritic cells. Molecular Immunology, Elsevier, 2021, 135, pp.165-169. ⟨10.1016/j.molimm.2021.04.012⟩. ⟨inserm-03381917⟩

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