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Hepatic sexual dimorphism -implications for non-alcoholic fatty liver disease

Abstract : The liver is often thought of as a single functional unit, but both its structural and functional architecture make it highly multivalent and adaptable. In any given physiological situation, the liver can maintain metabolic homeostasis, conduct appropriate inflammatory responses, carry out endobiotic and xenobiotic transformation and synthesis reactions, as well as store and release multiple bioactive molecules. Moreover, the liver is a very resilient organ. This resilience means that chronic liver diseases can go unnoticed for decades, yet culminate in life-threatening clinical complications once the liver is no longer able to compensate for them. Non-alcoholic fatty liver disease (NAFLD) predisposes individuals to cirrhosis and increases liver-related and cardiovascular disease-related mortality. This Review discusses the accumulating evidence of sexual dimorphism in NAFLD, which is currently rarely considered in preclinical and clinical studies. Increased awareness of hepatic sexual dimorphism could lead to improved understanding of the biological processes that are dysregulated in NAFLD, to the identification of relevant therapeutic targets and to improved risk stratification of patients with NAFLD undergoing therapeutic intervention.
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Contributor : Marie-Hélène Derudas Connect in order to contact the contributor
Submitted on : Monday, October 18, 2021 - 9:38:05 AM
Last modification on : Wednesday, March 23, 2022 - 3:51:33 PM
Long-term archiving on: : Wednesday, January 19, 2022 - 6:36:07 PM


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Philippe Lefebvre, Bart Staels. Hepatic sexual dimorphism -implications for non-alcoholic fatty liver disease. Nature Reviews Endocrinology, Nature Publishing Group, 2021, 17 (11), pp.662-670. ⟨10.1038/s41574-021-00538-6⟩. ⟨inserm-03381913⟩



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