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Studying the Structural Organization of Polyribosomes with Alexander S. Spirin

Abstract : "Would it be possible to analyze molecular mechanisms and structural organisation of polyribosome assemblies using cryo electron tomography?" - we asked through a longstanding collaboration between my research group and that of Alexander S. Spirin. Indeed, it was: we found that double-row polyribosomes can have both circular and linear arrangements of their mRNA [Afonina, Z. A., et al. (2013) Biochemistry (Moscow)], we figured out how eukaryotic ribosomes assemble on an mRNA to form supramolecular left-handed helices [Myasnikov, A. G., et al. (2014) Nat. Commun.], that the circularization of polyribosomes is poly-A and cap-independent [Afonina, Z. A., et al. (2014) Nucleic Acids Res.], and that intermediary polyribosomes with open structures exist after a transition from a juvenile phase to strongly translating polysomes of medium size [Afonina, Z. A., et al. (2015) Nucleic Acids Res.] until they form densely packed helical structures with reduced activity. Our joint fruitful exchanges, hence, led to major advances in the field, which are reviewed here from a personal and historical perspective in memory of Alexander S. Spirin.
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Submitted on : Wednesday, October 13, 2021 - 4:02:14 PM
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Bruno Klaholz. Studying the Structural Organization of Polyribosomes with Alexander S. Spirin. Биохимия / Biochemistry, MAIK Nauka/Interperiodica, 2021, 86 (9), pp.1053-1059. ⟨10.1134/S0006297921090030⟩. ⟨inserm-03376653⟩



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