Skip to Main content Skip to Navigation
Journal articles

Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases

Abstract : Sphingolipids are complex lipids. They play a structural role in neurons, but are also involved in regulating cellular communication, and neuronal differentiation and maturation. There is increasing evidence to suggest that dysregulated metabolism of sphingolipids is linked to neurodegenerative processes in amyotrophic lateral sclerosis (ALS), Parkinson's disease and Gaucher's disease. In this review, we provide an overview of the role of sphingolipids in the development and maintenance of the nervous system. We describe the implications of altered metabolism of sphingolipids in the pathophysiology of certain neurodegenerative diseases, with a primary focus on ALS. Finally, we provide an update of potential treatments that could be used to target the metabolism of sphingolipids in neurodegenerative diseases.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03376327
Contributor : Stéphane Dieterle Connect in order to contact the contributor
Submitted on : Wednesday, October 13, 2021 - 2:07:58 PM
Last modification on : Tuesday, October 19, 2021 - 3:33:22 AM

File

1-s2.0-S1084952120301038-main....
Publication funded by an institution

Identifiers

Collections

Citation

Alexandra Bouscary, Cyril Quessada, Frédérique René, Michael Spedding, Bradley Turner, et al.. Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Seminars in Cell and Developmental Biology, Elsevier, 2021, 112, pp.82-91. ⟨10.1016/j.semcdb.2020.10.008⟩. ⟨inserm-03376327⟩

Share

Metrics

Record views

6

Files downloads

22