Skip to Main content Skip to Navigation
Journal articles

Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer

Luc Ollivier 1, 2 Maureen Labbé 3, 2 Delphine Fradin 3 Vincent Potiron 1, 2 Stéphane Supiot 1, 2
2 CRCINA-ÉQUIPE 9 - Apoptosis and Tumor Progression
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
3 CRCINA-ÉQUIPE 4 - Immunogenic Cell Death and Mesothelioma Therapy
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Prostate cancer is the most frequently diagnosed cancer in men and a leading cause of cancer-related death. In recent decades, the development of immunotherapies has resulted in great promise to cure metastatic disease. However, prostate cancer has failed to show any significant response, presumably due to its immunosuppressive microenvironment. There is therefore growing interest in combining immunotherapy with other therapies able to relieve the immunosuppressive microenvironment. Radiation therapy remains the mainstay treatment for prostate cancer patients, is known to exhibit immunomodulatory effects, depending on the dose, and is a potent inducer of immunogenic tumor cell death. Optimal doses of radiotherapy are thus expected to unleash the full potential of immunotherapy, improving primary target destruction with further hope of inducing immune-cell-mediated elimination of metastases at distance from the irradiated site. In this review, we summarize the current knowledge on both the tumor immune microenvironment in prostate cancer and the effects of radiotherapy on it, as well as on the use of immunotherapy. In addition, we discuss the utility to combine immunotherapy and radiotherapy to treat oligometastatic metastatic prostate cancer.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03369787
Contributor : Delphine Fradin Connect in order to contact the contributor
Submitted on : Thursday, October 7, 2021 - 3:33:52 PM
Last modification on : Wednesday, October 20, 2021 - 8:44:36 AM

File

fonc-11-744679-2.pdf
Publisher files allowed on an open archive

Identifiers

Collections

`

Citation

Luc Ollivier, Maureen Labbé, Delphine Fradin, Vincent Potiron, Stéphane Supiot. Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer. Frontiers in Oncology, Frontiers, 2021, 11, pp.744679. ⟨10.3389/fonc.2021.744679⟩. ⟨inserm-03369787⟩

Share

Metrics

Record views

25

Files downloads

12