Skip to Main content Skip to Navigation
Journal articles

The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells

Abstract : Cell death receptors have crucial roles in the regulation of immune responses. Here we review recent in vivo data confirming that the Fas death receptor (TNFSR6) on B cells is important for the regulation of autoimmunity since the impairment of only Fas function on B cells results in uncontrolled autoantibody production and autoimmunity. Fas plays a role in the elimination of the non-specific and autoreactive B cells in germinal center, while during the selection of antigen-specific B cells different escape signals ensure the resistance to Fas-mediated apoptosis. Antigen-specific survival such as BCR or MHCII signal or coreceptors (CD19) cooperating with BCR inhibits the formation of death inducing signaling complex. Antigen-specific survival can be reinforced by antigen-independent signals of IL-4 or CD40 overproducing the anti-apoptotic members of the Bcl-2 family proteins.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03361008
Contributor : Anne-Odile Hueber Connect in order to contact the contributor
Submitted on : Friday, October 1, 2021 - 10:23:33 AM
Last modification on : Wednesday, October 6, 2021 - 3:28:48 AM

File

fimmu-03-00207.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Gabor Koncz, Anne-Odile Hueber. The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells. Frontiers in Immunology, Frontiers, 2012, 3, pp.207. ⟨10.3389/fimmu.2012.00207⟩. ⟨inserm-03361008⟩

Share

Metrics

Record views

2

Files downloads

1