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Journal Articles Neurology Year : 2021

Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

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Sheila Ouriques Martins
  • Function : Author
Hiroshi Yamagami
  • Function : Author
Zhongming Qiu
  • Function : Author
Ossama Yassin Mansour
  • Function : Author
Anvitha Sathya
  • Function : Author
Anna Czlonkowska
  • Function : Author
Georgios Tsivgoulis
Diana Aguiar de Sousa
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Jelle Demeestere
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Robert Mikulik
  • Function : Author
Peter Vanacker
  • Function : Author
James Siegler
  • Function : Author
Janika Kõrv
  • Function : Author
Jose Biller
  • Function : Author
Conrad Liang
  • Function : Author
Navdeep Sangha
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Alicia Zha
  • Function : Author
Alexandra Czap
  • Function : Author
Christine Anne Holmstedt
  • Function : Author
George Ntaios
Konark Malhotra
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Ashis Tayal
  • Function : Author
Aaron Loochtan
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Annamarei Ranta
  • Function : Author
Eva Mistry
  • Function : Author
Anne Alexandrov
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David Huang
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Shadi Yaghi
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Eytan Raz
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Sunil Sheth
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Eric Guemekane Bila Lamou
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Hany Aref
  • Function : Author
Ahmed Elbassiouny
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Farouk Hassan
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Tarek Menecie
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Wessam Mustafa
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Hossam Shokri
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Tamer Roushdy
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Fred Sarfo
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Tolulope Oyetunde Alabi
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Babawale Arabambi
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Ernest Nwazor
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Taofiki Ajao Sunmonu
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Kolawole Wahab
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Joseph Yaria
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Haytham Hussein Mohammed
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Philip Adebayo
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Anis Riahi
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Samia Ben Sassi
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Lenon Gwaunza
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Gift Wilson Ngwende
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David Sahakyan
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Aminur Rahman
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Zhibing Ai
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Fanghui Bai
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Zhenhui Duan
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Yonggang Hao
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Wenguo Huang
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Guangwen Li
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Wei Li
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Ganzhe Liu
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Jun Luo
Xianjin Shang
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Yi Sui
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Ling Tian
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Hongbin Wen
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Bo Wu
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Yuying Yan
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Zhengzhou Yuan
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Hao Zhang
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Jun Zhang
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Wenlong Zhao
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Wenjie Zi
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Thomas Leung
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Vikram Huded
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Bindu Menon
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Jeyaraj Durai Pandian
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Pn Sylaja
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Fritz Sumantri Usman
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Mehdi Farhoudi
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Elyar Sadeghi Hokmabadi
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Anat Horev
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Anna Reznik
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Rotem Sivan Hoffmann
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Nobuyuki Ohara
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Nobuyuki Sakai
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Daisuke Watanabe
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Ryoo Yamamoto
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Ryosuke Doijiri
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Naoki Tokuda
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Takehiro Yamada
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Tadashi Terasaki
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Yukako Yazawa
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Takeshi Uwatoko
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Tomohisa Dembo
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Hisao Shimizu
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Yuri Sugiura
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Fumio Miyashita
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Hiroki Fukuda
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Kosuke Miyake
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Junsuke Shimbo
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Yusuke Sugimura
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Yoshiki Yagita
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Yohei Takenobu
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Yuji Matsumaru
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Satoshi Yamada
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Ryuhei Kono
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Takuya Kanamaru
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Hidekazu Yamazaki
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Manabu Sakaguchi
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Kenichi Todo
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Nobuaki Yamamoto
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Kazutaka Sonoda
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Tomoko Yoshida
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Hiroyuki Hashimoto
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Ichiro Nakahara
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Aida Kondybayeva
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Kamila Faizullina
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Saltanat Kamenova
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Murat Zhanuzakov
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Jang-Hyun Baek
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Yangha Hwang
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Jin Soo Lee
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Si Baek Lee
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Jusun Moon
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Hyungjong Park
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Jung Hwa Seo
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Kwon-Duk Seo
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Sung Il Sohn
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Chang Jun Young
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Rechdi Ahdab
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Wan Asyraf Wan Zaidi
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Zariah Abdul Aziz
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Hamidon Bin Basri
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Law Wan Chung
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Aznita Binti Ibrahim
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Khairul Azmi Ibrahim
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Irene Looi
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Wee Yong Tan
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Nafisah Wan Yahya
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Stanislav Groppa
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Pavel Leahu
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Amal Al Hashmi
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Yahia Zakaria Imam
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Naveed Akhtar
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Maria Carissa Pineda-Franks
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Christian Oliver Co
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Dmitriy Kandyba
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Adel Alhazzani
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Hosam Al-Jehani
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Carol Huilian Tham
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Marlie Jane Mamauag
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Chih-Hao Chen
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Sung-Chun Tang
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Anchalee Churojana
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Esref Akil
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Özlem Aykaç
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Atilla Ozcan Ozdemir
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Semih Giray
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Syed Irteza Hussain
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Seby John
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Huynh Le Vu
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Anh Duc Tran
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Huy Hoang Nguyen
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Thong Nhu Pham
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Thang Huy Nguyen
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Trung Quoc Nguyen
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Thomas Gattringer
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Christian Enzinger
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Monika Killer-Oberpfalzer
Flavio Bellante
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Sofie de Blauwe
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Geert Vanhooren
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Sylvie de Raedt
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Anne Dusart
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Robin Lemmens
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Noemie Ligot
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Matthieu Pierre Rutgers
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Laetitia Yperzeele
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Filip Alexiev
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Teodora Sakelarova
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Marina Roje Bedeković
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Hrvoje Budincevic
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Igor Cindric
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Zlatko Hucika
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David Ozretic
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Majda Seferovic Saric
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František Pfeifer
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Igor Karpowic
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David Cernik
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Martin Sramek
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Miroslav Skoda
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Helena Hlavacova
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Lukas Klecka
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Martin Koutny
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Daniel Vaclavik
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Ondrej Skoda
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Jan Fiksa
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Katerina Hanelova
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Miroslava Nevsimalova
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Robert Rezek
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Petr Prochazka
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Gabriela Krejstova
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Jiri Neumann
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Marta Vachova
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Henryk Brzezanski
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David Hlinovsky
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Dusan Tenora
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Rene Jura
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Lubomír Jurák
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Jan Novak
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Ales Novak
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Zdenek Topinka
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Petr Fibrich
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Helena Sobolova
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Ondrej Volny
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Hanne Krarup Christensen
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Nicolas Drenck
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Helle Klingenberg Iversen
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Claus Simonsen
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Thomas Clement Truelsen
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Troels Wienecke
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Riina Vibo
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Katrin Gross-Paju
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Toomas Toomsoo
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Katrin Antsov
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Charlotte Cordonnier
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Maria Dan
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Jean-Marc Faucheux
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Laura Mechtouff
Omer Eker
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Emilie Lesaine
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Basile Ondze
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Roxane Peres
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Fernando Pico
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Michel Piotin
Raoul Pop
Francois Rouanet
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Tatuli Gubeladze
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Mirza Khinikadze
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Nino Lobjanidze
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Alexander Tsiskaridze
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Simon Nagel
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Peter Arthur Ringleb
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Michael Rosenkranz
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Holger Schmidt
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Annahita Sedghi
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Timo Siepmann
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Kristina Szabo
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Götz Thomalla
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Lina Palaiodimou
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Dimitrios Sagris
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Odysseas Kargiotis
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Peter Klivenyi
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Laszlo Szapary
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Gabor Tarkanyi
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Alessandro Adami
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Fabio Bandini
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Paolo Calabresi
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Giovanni Frisullo
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Leonardo Renieri
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Davide Sangalli
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Anne Pirson
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Maarten Uyttenboogaart
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Ido van den Wijngaard
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Espen Saxhaug Kristoffersen
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Waldemar Brola
Małgorzata Fudala
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Ewa Horoch-Lyszczarek
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Michal Karlinski
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Radoslaw Kazmierski
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Pawel Kram
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Marcin Rogoziewicz
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Rafal Kaczorowski
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Piotr Luchowski
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Halina Sienkiewicz-Jarosz
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Piotr Sobolewski
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Waldemar Fryze
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Anna Wisniewska
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Malgorzata Wiszniewska
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Patricia Ferreira
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Paulo Ferreira
Luisa Fonseca
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João Pedro Marto
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Teresa Pinho E Melo
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Ana Paiva Nunes
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Miguel Rodrigues
Vítor Tedim Cruz
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Cristian Falup-Pecurariu
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Georgi Krastev
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Miroslav Mako
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María Alonso de Leciñana
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Juan Arenillas
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Oscar Ayo-Martin
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Antonio Cruz Culebras
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Exuperio Diez Tejedor
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Joan Montaner
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Soledad Pérez-Sánchez
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Miguel Angel Tola Arribas
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Alejandro Rodriguez Vasquez
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Michael Mayza
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Gianmarco Bernava
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Alex Brehm
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Paolo Machi
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Urs Fischer
Jan Gralla
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Patrik Michel
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Marios-Nikos Psychogios
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Davide Strambo
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Soma Banerjee
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Kailash Krishnan
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Joseph Kwan
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Asif Butt
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Luciana Catanese
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Andrew Demchuk
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Thalia Field
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Jennifer Haynes
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Michael Hill
Houman Khosravani
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Ariane Mackey
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Aleksandra Pikula
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Gustavo Saposnik
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Courtney Anne Scott
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Ashkan Shoamanesh
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Ashfaq Shuaib
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Miguel Barboza
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Jose Domingo Barrientos
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Ligia Ibeth Portillo Rivera
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Fernando Gongora-Rivera
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Anmylene Blanco
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Anthony Alvarado-Ortiz
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Aamir Badruddin
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Nobl Barazangi
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Charmaine Brereton
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Alicia Castonguay
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Seemant Chaturvedi
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Saqib Chaudry
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Hana Choe
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Jae Choi
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Kinjal Desai
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Vinodh Doss
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Randall Edgell
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Mark Etherton
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Mudassir Farooqui
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Don Frei
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Dheeraj Gandhi
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Mikayel Grigoryan
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Rishi Gupta
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Ameer Hassan
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Johanna Helenius
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Artem Kaliaev
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Ritesh Kaushal
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Priyank Khandelwal
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Naim Khoury
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Benny Kim
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Dawn Kleindorfer
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Feliks Koyfman
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Vivien Lee
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Lester Leung
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Guillermo Linares
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Italo Linfante
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Helmi Lutsep
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Lisa Macdougall
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Shailesh Male
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Amer Malik
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Hesham Masoud
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Molly Mcdermott
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Brijesh Mehta
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Jiangyong Min
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Manoj Mittal
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Jane Morris
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Sumeet Multani
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Fadi Nahab
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Krishna Nalleballe
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Claude Nguyen
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Roberta Novakovic-White
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Santiago Ortega-Gutierrez
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Rahul Rahangdale
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Pankajavalli Ramakrishnan
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Jose Rafael Romero
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Natalia Rost
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Aaron Rothstein
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Sean Ruland
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Ruchir Shah
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Malveeka Sharma
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Brian Silver
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Marc Simmons
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Abhishek Singh
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Amy Starosciak
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Sheryl Strasser
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Viktor Szeder
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Mohamed Teleb
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Jenny Tsai
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Barbara Voetsch
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Oscar Balaguera
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Virginia Pujol Lereis
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Adriana Luraschi
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Marcele Schettini Almeida
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Fabricio Buchdid Cardoso
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Adriana Conforto
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Leonardo de Deus Silva
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Luidia Varrone Giacomini
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Fabricio Oliveira Lima
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Alexandre Longo
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Pedro Magalhães
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Rodrigo Targa Martins
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Francisco Mont'Alverne
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Daissy Liliana Mora Cuervo
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Leticia Costa Rebello
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Lenise Valler
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Viviane Flumignan Zetola
  • Function : Author
Pablo Lavados
  • Function : Author
Victor Navia
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Verónica Olavarría
  • Function : Author
Juan Manuel Almeida Toro
  • Function : Author
Pablo Felipe Ricardo Amaya
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Hernan Bayona
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Angel Corredor
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Carlos Eduardo Rivera Ordonez
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Osvaldo Lara
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Mauricio Patiño
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Luis Fernando Diaz Escobar
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Analia Cardozo Villamayor
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Adolfo Javier Zelaya Zarza
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Danny Moises Barrientos Iman
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Liliana Rodriguez Kadota
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Bruce Campbell
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Graeme Hankey
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Casey Hair
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Timothy Kleinig
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Alice Ma
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Rodrigo Tomazini Martins
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Ramesh Sahathevan
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Vincent Thijs
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Daniel Salazar
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Teddy Yuan-Hao Wu
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Diogo Haussen
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David Liebeskind
Dileep Yavagal
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Tudor Jovin
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Osama Zaidat
Thanh Nguyen
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Pedro S.C. Magalhães
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Abstract

Objective To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] −11.7 to −11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI −13.8 to −12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI −13.7 to −10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2–9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

Dates and versions

inserm-03356024 , version 1 (27-09-2021)

Identifiers

Cite

Raul Nogueira, Muhammad Qureshi, Mohamad Abdalkader, Sheila Ouriques Martins, Hiroshi Yamagami, et al.. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis. Neurology, 2021, 96 (23), pp.e2824-e2838. ⟨10.1212/WNL.0000000000011885⟩. ⟨inserm-03356024⟩

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