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Impact of hepatitis C virus coinfection on T-cell dynamics in long-term HIV-suppressors under combined antiretroviral therapy

Abstract : Objective: The objective of this study is to evaluate the impact of hepatitis C virus (HCV) serostatus on the evolution of CD8 þ cells and CD4 þ : CD8 þ ratio in HIV-infected patients on combined antiretroviral therapy (cART) who achieve sustained undetectable viral load (HIV-pVL). Design and methods: A longitudinal study performed in an outpatient HIV-unit following 1495 HIV-infected patients. Data of patients on cART achieving undetectable HIV-pVL for at least 3 years were collected retrospectively from our medical e-database NADIS from January 1997 to April 2005, a period defined in order to select patients who were naive of hepatitis treatment. T-cell counts were assessed every 6 months from HIVsuppression over the study period. Results: Two hundred and twenty-six HIV mono-infected (group 1) and 130 HCVcoinfected patients (group 2; genotype prevalence: 42% HCV-G1, 26% HCV-G3, 11% HCV-G4 and 21% HCV-G2) fulfilled the selection criteria. cART regimens were comparable between the groups, as were CD4 þ and CD8 þ cell counts at the first undetectable HIV-pVL. After 3 years, both groups displayed similar CD4 þ cell reconstitution, although CD4 þ percentage was higher in group 1 (30.3 AE 1.1 vs. 27 AE 1.1%; P < 0.001). HIV suppression led to a significant drop of median CD8 þ cell counts in group 1 (P ¼ 0.027), but not in group 2, which displayed higher CD8 þ cell counts all through the follow-up (mean diff. ¼ 135.71 AE 26.89 cells/ml, P < 0.001). Moreover, the fraction of patients reaching CD4 þ : CD8 þ ratio ! 1 was lower in group 2 (14 vs. 27.7%; P < 0.05). Conclusion: Despite sustained HIV suppression under cART, HCV coinfection was found to hamper CD8 þ downregulation. Further studies will determine the impact of treatment with direct-acting antiviral agents on the CD8 þ pool, and the advantage of systematic HCV-targeted therapy for HIV/HCV-coinfected patients.
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https://www.hal.inserm.fr/inserm-03353987
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Submitted on : Friday, September 24, 2021 - 3:07:49 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:39 PM

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Olivia Zaegel-Faucher, Sylvie Bregigeon, Carla Cano, Véronique Obry-Roguet, Corinne Nicolino-Brunet, et al.. Impact of hepatitis C virus coinfection on T-cell dynamics in long-term HIV-suppressors under combined antiretroviral therapy. AIDS, Lippincott, Williams & Wilkins, 2015, 29 (12), pp.1505 - 1510. ⟨10.1097/qad.0000000000000650⟩. ⟨inserm-03353987⟩

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