Skip to Main content Skip to Navigation
Journal articles

HLA class II-restricted recognition of common tumor epitopes on human melanoma cells by CD4+ melanoma-infiltrating lymphocytes

Abstract : CD4+ T cell clones derived from lymphocytes infiltrating four human melanomas specifically recognized melanoma-derived tumor epitopes as shown by secretion of tumor necrosis factor (TNF) in vitro upon interaction with autologous melanoma cells, whereas they did not recognize HLA class II-expressing autologous lymphoblasts or HLA class II mismatched allogeneic melanoma cells. Specificity was further established by demonstrating that TNF responses to tumor cells were inhibited by HLA-DR or HLA-DQ monoclonal antibodies. Most of these clones cross-reacted with allogeneic melanoma cells expressing a potentially restricting HLA allele or a structurally similar one. These data show that shared epitopes of human melanoma cells presented on HLA class II molecules are frequently recognized by autologous CD4+ T lymphocytes.
Document type :
Journal articles
Complete list of metadata

https://www.hal.inserm.fr/inserm-03350939
Contributor : Nadine Gervois Connect in order to contact the contributor
Submitted on : Tuesday, September 21, 2021 - 5:15:28 PM
Last modification on : Wednesday, September 22, 2021 - 3:16:25 AM

File

eji.1830251003.pdf
Files produced by the author(s)

Identifiers

Collections

`

Citation

Eric Le Dréan, Nadine Gervois, Elisabeth Diez, Gilbert Semana, Brigitte Dreno, et al.. HLA class II-restricted recognition of common tumor epitopes on human melanoma cells by CD4+ melanoma-infiltrating lymphocytes. European Journal of Immunology, Wiley-VCH Verlag, 1995, 25 (10), pp.2732-2736. ⟨10.1002/eji.1830251003⟩. ⟨inserm-03350939⟩

Share

Metrics

Record views

26

Files downloads

14