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Vasculogenic mimicry, a complex and devious process favoring tumorigenesis -Interest in making it a therapeutic target

Lucas Treps 1 Sébastien Faure 2 Nicolas Clere 2, * 
* Corresponding author
1 CRCINA-ÉQUIPE 4 - Immunogenic Cell Death and Mesothelioma Therapy
CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
Abstract : Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the plasticity of aggressive cancer cells forming de novo vascular networks and is associated with the malignant phenotype and poor clinical outcome. VM is described in a plethora of tumors, including carcinomas, sarcomas, glioblastomas, astrocytomas and melanomas. The presence of VM is associated with a high tumor grade, short survival, invasion and metastasis. A variety of molecular mechanisms and signal pathways participates in VM induction and formation. Due to VM's contribution on tumor progression, more VM-related strategies are being utilized for anticancer treatment. After describing the main features of VM, this review will outline the importance of the tumor microenvironment during this process, and highlight the predominant molecular targets and signaling pathways involved. These data will make it possible to discuss the importance of VM-associated mediators in antitumor therapy and how it could allow to better understand the resistance to anticancer therapy.
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Submitted on : Tuesday, September 21, 2021 - 7:53:33 AM
Last modification on : Wednesday, April 27, 2022 - 4:45:13 AM
Long-term archiving on: : Wednesday, December 22, 2021 - 6:08:33 PM


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Lucas Treps, Sébastien Faure, Nicolas Clere. Vasculogenic mimicry, a complex and devious process favoring tumorigenesis -Interest in making it a therapeutic target. Pharmacology & Therapeutics Part A Chemotherapy Toxicology and Metabolic Inhibitors, Elsevier, 2021, 223, pp.107805. ⟨10.1016/j.pharmthera.2021.107805⟩. ⟨inserm-03349934⟩



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