Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-a, IFN-b…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.

Mots clés

lung cancer mesothelioma type I interferon CDKN2A (p16) homozygous deletion immunotherapy

Domaines

Cancer

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Grard2021Eq04.pdf (826.22 Ko)

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https://inserm.hal.science/inserm-03349933

Soumis le : mardi 21 septembre 2021-07:43:21

Dernière modification le : lundi 4 mars 2024-13:36:06

Archivage à long terme le : mercredi 22 décembre 2021-18:08:23

Dates et versions

inserm-03349933 , version 1 (21-09-2021)

Identifiants

HAL Id : inserm-03349933 , version 1
DOI : 10.3389/fonc.2021.695770
PUBMED : 34249754
PUBMEDCENTRAL : PMC8266377

Citer

Marion Grard, Camille Chatelain, Tiphaine Delaunay, Elvire Pons-Tostivint, Jaafar Bennouna, et al.. Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy. Frontiers in Oncology, 2021, 11, pp.695770. ⟨10.3389/fonc.2021.695770⟩. ⟨inserm-03349933⟩

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