Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy

Homozygous deletion (HD) of the tumor suppressor gene CDKN2A is the most frequent genetic alteration in malignant pleural mesothelioma and is also frequent in non-small cell lung cancers. This HD is often accompanied by the HD of the type I interferons (IFN I) genes that are located closed to the CDKN2A gene on the p21.3 region of chromosome 9. IFN I genes encode sixteen cytokines (IFN-a, IFN-b…) that are implicated in cellular antiviral and antitumor defense and in the induction of the immune response. In this review, we discuss the potential influence of IFN I genes HD on thoracic cancers therapy and speak in favor of better taking these HD into account in patients monitoring.

Keywords

lung cancer mesothelioma type I interferon CDKN2A (p16) homozygous deletion immunotherapy

Domains

Cancer

Fichier principal

Grard2021Eq04.pdf (826.22 Ko)

Origin : Publisher files allowed on an open archive

Elizabeth Bernardo : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-03349933

Submitted on : Tuesday, September 21, 2021-7:43:21 AM

Last modification on : Thursday, April 13, 2023-1:30:07 PM

Long-term archiving on: Wednesday, December 22, 2021-6:08:23 PM

Dates and versions

inserm-03349933 , version 1 (21-09-2021)

Identifiers

HAL Id : inserm-03349933 , version 1
DOI : 10.3389/fonc.2021.695770
PUBMED : 34249754
PUBMEDCENTRAL : PMC8266377

Cite

Marion Grard, Camille Chatelain, Tiphaine Delaunay, Elvire Pons-Tostivint, Jaafar Bennouna, et al.. Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy. Frontiers in Oncology, 2021, 11, pp.695770. ⟨10.3389/fonc.2021.695770⟩. ⟨inserm-03349933⟩

Export

BibTeX TEI Dublin Core DC Terms EndNote Datacite

Collections

INSERM UNIV-NANTES CNRS UNIV-ANGERS CRCINA NANTES-UNIVERSITE

23 View

23 Download