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Relevance of KIR gene matching in unrelated hematopoietic stem cell transplantations

Katia Gagne 1, 2 M Busson 3 M Balere-Appert 4 L Absi 5 I Jollet 6 J-D Bignon 1, 2 M Bois 6 A Dormoy 7 V Dubois 8 L Gebuhrer 8 P Loiseau 9 D Masson 10 A Moine 10 P Perrier 11 D Reviron 12 D Charron 3 C Raffoux 4
1 Etablissement Français du Sang [Nantes]
2 CIC biothérapies CBT 0503 [Nantes]
3 Réponses immunes : régulation et développement
4 RFGM - Registre France Greffe de Moelle [Saint-Denis La Plaine]
5 EFS - Etablissement français du sang, Auvergne-Loire [Saint-Etienne]
6 EFS - Etablissement français du sang [Poitiers]
7 EFS - alsace strasbourg - Etablissement Français du Sang - Grand Est
8 EFS - Etablissement français du sang - Auvergne-Rhône-Alpes
9 Laboratoire Jean Dausset d'Immunologie et d'Histocompatibilité [AP-HP Hôpital Saint-Louis]
10 EFS - Etablissement Français du Sang [Grenoble]
11 Laboratoire d'histocompatibilité [CHRU Nancy]
12 EFS - Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse
Abstract : The aim of this collaborative study was to evaluate the impact of killer cell immunoglobulin-like receptor (KIR) gene disparities on unrelated hematopoietic stem cell transplantations (HSCT) outcome. To address this question, we have determined the presence or absence of 14 functional KIR genes in HLA-matched (n= 164) or HLA-mismatched (n= 100) donor/recipient pairs and investigated whether KIR gene disparities had an impact on both the occurrence of acute graft-vs-host-disease incidence and overall survival. In a univariate analysis, our preliminary results suggest a detrimental effect of a few KIR gene disparities on patient survival that should be avoided in unrelated HSCT.
Keywords : graft-vs-host-disease killer cell immunoglobulin-like receptor KIR gene matching survival unrelated hematopoietic stem cell transplantation
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Journal articles
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https://www.hal.inserm.fr/inserm-03349742
Contributor : Katia Gagne Connect in order to contact the contributor
Submitted on : Monday, September 20, 2021 - 4:57:38 PM
Last modification on : Saturday, January 15, 2022 - 3:43:40 AM
Long-term archiving on: : Tuesday, December 21, 2021 - 7:18:55 PM

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INSERM | UNIV-PARIS7 | UNIV-PARIS

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Katia Gagne, M Busson, M Balere-Appert, L Absi, I Jollet, et al.. Relevance of KIR gene matching in unrelated hematopoietic stem cell transplantations. Tissue Antigens, Wiley, 2007, 69 (Suppl 1), pp.118 - 122. ⟨10.1111/j.1399-0039.2006.76210.x⟩. ⟨inserm-03349742⟩

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