CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy (Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEX
Hôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy
Hôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-Nancy
Maternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy - France)
Abstract : The aim of this collaborative study was to evaluate the impact of killer cell immunoglobulin-like receptor (KIR) gene disparities on unrelated hematopoietic stem cell transplantations (HSCT) outcome. To address this question, we have determined the presence or absence of 14 functional KIR genes in HLA-matched (n= 164) or HLA-mismatched (n= 100) donor/recipient pairs and investigated whether KIR gene disparities had an impact on both the occurrence of acute graft-vs-host-disease incidence and overall survival. In a univariate analysis, our preliminary results suggest a detrimental effect of a few KIR gene disparities on patient survival that should be avoided in unrelated HSCT.
https://www.hal.inserm.fr/inserm-03349742 Contributor : Katia GAGNEConnect in order to contact the contributor Submitted on : Monday, September 20, 2021 - 4:57:38 PM Last modification on : Saturday, January 15, 2022 - 3:43:40 AM Long-term archiving on: : Tuesday, December 21, 2021 - 7:18:55 PM
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Katia Gagne, M Busson, M L Balere-Appert, L Absi, I Jollet, et al.. Relevance of KIR gene matching in unrelated hematopoietic stem cell transplantations. Tissue Antigens, Wiley, 2007, 69 (Suppl 1), pp.118 - 122. ⟨10.1111/j.1399-0039.2006.76210.x⟩. ⟨inserm-03349742⟩