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Identification of a new HLA-DRB1 allele, DRB1*0321

Abstract : This communication reports the identification of a new HLA-DRB1*03 allele identified in three members of a Caucasian French family. This new allele has been officially named HLA-DRB1*0321 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB1*0321 is identical to that of DRB1*0307 except for the first and second nucleotides of codon 37 (TT replacing AA), which lead to the substitution of a tyrosine for a phenylalanine (AAC»TTC at position 37). The family study showed that this new allele was transmitted into the HLA-A*0101/09,-B*0801/14,-Cw*0701,-DRB1*0321,-DRB3*0101,-DQB1*0503 and-DPB1*0401 haplotype. The complete exon 2 sequence of this new allele has been previously deposited in the EMBL Sequence Database under accession number AF297266.
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Submitted on : Monday, September 20, 2021 - 4:54:41 PM
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Katia Gagne, F Bonneville, M.-L Cheneau, P Herry, M.-J Pinson, et al.. Identification of a new HLA-DRB1 allele, DRB1*0321. Tissue Antigens, Wiley, 2002, 60, pp.268-270. ⟨10.1034/j.1399-0039.2002.600311.x⟩. ⟨inserm-03349735⟩



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