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Éligibilité des patients aux cellules CAR-T : avis d’experts proposé par la SFGM-TC

David Beauvais 1, 2 Emmanuel Bachy 3, 4 André Baruchel 5, 6 Jacques-Olivier Bay 7 Denis Caillot 8 Guillaume Cartron 9, 10 Gandhi Damaj 11, 12 Sabine Furst 13 Steven Le Gouill 14 Franck Morschhauser 15, 1, 2 Florence Rabian 5, 16 Marie-Thérèse Rubio 17, 18 Catherine Thieblemont 19, 20, 21 Ibrahim yakoub-Agha 22 
Abstract : The chimeric antigen receptor T-cells are a new class of anticancer treatment consisting in genetically modifying autologous or allogenic T-cells to make express a CAR directed against a membrane tumor antigen. In Europe, tisagenlecleucel (KymriahTM) has a marketing authorization for the treatment of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia in children and young adults and of R/R diffuse large B-cell lymphoma (DLBCL). The marketing authorization for axicabtagene ciloleucel (YescartaTM) is the treatment of DLBCL and primary R/R mediastinal B-cell lymphoma. The two products are autologous T-cells directed against CD19. This collaborative work, part of a series of expert opinion-based work, aims to give practical advice to help centers in selection of patients for commercially available CAR T-cell treatment.
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Submitted on : Monday, September 20, 2021 - 10:59:27 AM
Last modification on : Tuesday, May 17, 2022 - 2:20:03 PM
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David Beauvais, Emmanuel Bachy, André Baruchel, Jacques-Olivier Bay, Denis Caillot, et al.. Éligibilité des patients aux cellules CAR-T : avis d’experts proposé par la SFGM-TC. Bulletin du Cancer, John Libbey Eurotext, 2021, 108 (7-8), pp.725-729. ⟨10.1016/j.bulcan.2020.10.017⟩. ⟨inserm-03349011⟩



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