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Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor 1

Abstract : Human NK cells and subsets of T cells or NKT cells express the orphan C-type lectin receptor CD161 (NKR-P1A) of unknown function. In contrast to rodents that possess several NKR-P1 genes coding for either activating or inhibitory receptors, the nature of signals delivered by the single human NKR-P1A receptor is still to be clarified. In this article, we show that the lectin-like transcript 1 (LLT1) molecule is a ligand for the CD161 receptor. Engagement of CD161 on NK cells with LLT1 expressed on target cells inhibited NK cell-mediated cytotoxicity and IFN-␥ secretion. Conversely, LLT1/CD161 interaction in the presence of a TCR signal enhanced IFN-␥ production by T cells. These findings identify a novel ligand/receptor pair that differentially regulate NK and T cell functions.
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https://www.hal.inserm.fr/inserm-03346776
Contributor : Christelle Retiere Connect in order to contact the contributor
Submitted on : Thursday, September 16, 2021 - 3:56:45 PM
Last modification on : Friday, September 17, 2021 - 3:23:39 AM

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Hatice Aldemir, Virginie Prod'Homme, Marie-Jeanne Dumaurier, Christelle Retiere, Gwenola Poupon, et al.. Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor 1. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2005, 175 (12), pp.7791-5. ⟨10.4049/jimmunol.175.12.7791⟩. ⟨inserm-03346776⟩

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