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Eight-Year Follow-up of Hypnotic Delivery by Adults Aged 50 and Older from an Insurance Database

Abstract : Study objectives: This study sought to (1) identify patterns of hypnotic use among persons aged 50 and older for 8 years and (2) describe characteristics and correlates associated with them. Methods: A representative sample of national health insurance system beneficiaries was followed up from 2006 through 2013; individuals were grouped according to hypnotic delivery trajectories by latent class mixed models. Results: We identified four different temporal trajectories of hypnotic delivery among users. Delivery was occasional for 40% and regular for 60% (quasicontinuous "use": 27%; increasingly frequent over time: 17%; decreasingly frequent: 16%). Quasi-continuous "users" received hypnotics for more than 70% of the follow-up period and occasional "users" for less than 8%. We found no clear evidence of dose escalation. The three regular-delivery trajectories shared similar correlates (psychiatric disorders, somatic comorbidity, and coprescriptions of antidepressants or antipsychotics), but association with somatic comorbidity was highest by far for quasi-continuous "users." Conclusions: Our results suggest that chronic hypnotic use covers different patterns resulting from different long-term temporal delivery trajectories. Because difficulties in stopping or reducing use may vary greatly according to these trajectories, patients may need individualized management approaches.
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Submitted on : Monday, September 13, 2021 - 3:16:30 PM
Last modification on : Tuesday, September 6, 2022 - 4:23:49 PM


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Pierre Verger, Sébastien Cortaredona, Hélène Jacqmin-Gadda, Marie Tournier, Hélène Verdoux. Eight-Year Follow-up of Hypnotic Delivery by Adults Aged 50 and Older from an Insurance Database. SLEEP, Oxford University Press 2017, 40 (11), ⟨10.1093/sleep/zsx147⟩. ⟨inserm-03342689⟩



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