Skip to Main content Skip to Navigation
Journal articles

The Effect of Radiotherapy on Diffuse Low-Grade Gliomas Evolution: Confronting Theory with Clinical Data

Abstract : Diffuse low-grade gliomas are slowly growing tumors that always recur after treatment. In this paper, we revisit the modeling of the evolution of the tumor radius before and after the radiotherapy process and propose a novel model that is simple yet biologically motivated and that remedies some shortcomings of previously proposed ones. We confront this with clinical data consisting of time series of tumor radii from 43 patient records by using a stochastic optimization technique and obtain very good fits in all cases. Since our model describes the evolution of a tumor from the very first glioma cell, it gives access to the possible age of the tumor. Using the technique of profile likelihood to extract all of the information from the data, we build confidence intervals for the tumor birth age and confirm the fact that low-grade gliomas seem to appear in the late teenage years. Moreover, an approximate analytical expression of the temporal evolution of the tumor radius allows us to explain the correlations observed in the data.
Complete list of metadata

https://www.hal.inserm.fr/inserm-03341970
Contributor : Clara Martinez Rico <>
Submitted on : Monday, September 13, 2021 - 10:20:06 AM
Last modification on : Wednesday, September 15, 2021 - 3:09:48 AM

File

Adenis et al. J Pers Med. 2021...
Publisher files allowed on an open archive

Identifiers

Citation

Léo Adenis, Stéphane Plaszczynski, Basile Grammaticos, Johan Pallud, Mathilde Badoual. The Effect of Radiotherapy on Diffuse Low-Grade Gliomas Evolution: Confronting Theory with Clinical Data. Journal of Personalized Medicine, MDPI, 2021, 11 (8), pp.818. ⟨10.3390/jpm11080818⟩. ⟨inserm-03341970⟩

Share

Metrics

Record views

9

Files downloads

2