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Données récentes sur le mécanisme d'action de la metformine dans le diabète de type 2 Recent advances on elucidating the mechanism of metformin action in type 2 diabetes

Abstract : Metformin (dimethylbiguanide) is one of the oldest anti-diabetic drugs and remains the first-line pharmacological therapy for the management of type 2 diabetes. However, despite its use for several decades, the molecular mechanisms responsible for its antihyperglycemic effects remain controversial. Historically, the reduction of blood glucose levels by metformin has been attributed to the inhibition of hepatic gluconeogenesis, but emerging evidence suggests that extra-hepatic sites of action, such as the gastrointestinal tract, may also contribute to a similar extent as the liver in the control of glycemia.
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https://www.hal.inserm.fr/inserm-03341041
Contributor : Benoit Viollet <>
Submitted on : Friday, September 10, 2021 - 2:44:20 PM
Last modification on : Thursday, September 16, 2021 - 3:12:34 AM

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  • HAL Id : inserm-03341041, version 1

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Marc Foretz, Bruno Guigas, Benoit Viollet. Données récentes sur le mécanisme d'action de la metformine dans le diabète de type 2 Recent advances on elucidating the mechanism of metformin action in type 2 diabetes. Médecine des Maladies Métaboliques, Elsevier, A paraître. ⟨inserm-03341041⟩

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