Ketogenic diet impairs Mycobacterium ulcerans growth and toxin production, enhancing hosts’ response to the infection in an experimental mouse model - Archive ouverte HAL Access content directly
Journal Articles Journal of Infectious Diseases Year : 2021

Ketogenic diet impairs Mycobacterium ulcerans growth and toxin production, enhancing hosts’ response to the infection in an experimental mouse model

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Mélanie Foulon
  • Function : Author
  • PersonId : 1109777
Marie Robbe-Saule
Lucille Esnault
Estelle Marion
Laurent Marsollier

Abstract

Ketogenic diets have been used to treat diverse conditions, and there is growing evidence of their benefits for tissue repair and in inflammatory disease treatment. However, their role in infectious diseases has been little studied. Buruli ulcer (Mycobacterium ulcerans infection) is a chronic infectious disease characterized by large skin ulcerations caused by mycolactone, the major virulence factor of the bacillus. Here, we investigated the impact of ketogenic diet on this cutaneous disease in an experimental mouse model. This diet prevented ulceration, by modulating bacterial growth and host inflammatory response. β-hydroxybutyrate, the major ketone body produced during ketogenic diet and diffusing in tissues, impeded M. ulcerans growth and mycolactone production in vitro underlying its potential key role in infection. These results pave the way for the development of new patient management strategies involving shorter courses of treatment and improving wound healing, in line with the major objectives of the World Health Organization.
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Dates and versions

inserm-03339423 , version 1 (09-09-2021)

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Mélanie Foulon, Marie Robbe-Saule, Lucille Esnault, Marine Malloci, Anthony Mery, et al.. Ketogenic diet impairs Mycobacterium ulcerans growth and toxin production, enhancing hosts’ response to the infection in an experimental mouse model. Journal of Infectious Diseases, 2021, pp.jiab236. ⟨10.1093/infdis/jiab236⟩. ⟨inserm-03339423⟩
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