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A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients

Abstract : BACKGROUND: First-pass effect (FPE) defined as a complete or near-complete reperfusion achieved after a single thrombectomy pass is predictive of favorable outcome in acute ischemic stroke (AIS) patients. We aimed to assess whether admission levels of inflammatory markers are associated with FPE. METHODS: HIBISCUS-STROKE (CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke) includes AIS patients with large vessel occlusion treated with mechanical thrombectomy following brain MRI. C-reactive protein, interleukin (IL)-6, IL-8, IL-10, monocyte chemoattractant protein-1, soluble tumor necrosis factor receptor I, soluble form suppression of tumorigenicity 2, matrix metalloproteinase-9 (MMP-9), soluble P-selectin, and vascular cellular adhesion molecule-1 were measured in admission sera using an ELISA assay. FPE was defined as a complete or near-complete reperfusion (thrombolysis in cerebral infarction scale (TICI) 2c or 3) after the first pass. A multivariate logistic regression analysis was performed to assess independent factors associated with FPE. RESULTS: A total of 151 patients were included. Among them, 43 (28.5%) patients had FPE. FPE was associated with low admission levels of IL-6, MMP-9, and platelet count, an older age, lack of hypertension, lack of tandem occlusion, a shorter thrombus length, and a reduced procedural time. Following multivariate analysis, a low admission level of IL-6 was associated with FPE (OR 0.66, 95% CI 0.46 to 0.94). Optimal cut-off of IL-6 level for distinguishing FPE from non-FPE was 3.0 pg/mL (sensitivity 92.3%, specificity 42.3%). CONCLUSION: A lower admission level of IL-6 is associated with FPE.
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Submitted on : Wednesday, September 8, 2021 - 12:56:15 PM
Last modification on : Thursday, June 23, 2022 - 10:48:20 PM
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L. Mechtouff, T. Bochaton, A. Paccalet, C. Crola da Silva, M. Buisson, et al.. A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients. Journal of Neurointerventional Surgery, BMJ Journals, 2021, pp.neurintsurg-2021-017334. ⟨10.1136/neurintsurg-2021-017334⟩. ⟨inserm-03337974⟩



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